Κατάλογος Προσωπικού

ΠΑΡΗΣ ΣΚΟΥΡΙΔΗΣ

SKOURIDES PARIS
22892895
...
ΚΑΘΗΓΗΤΗΣ/ΡΙΑ
Τμήμα Βιολογικών Επιστημών
ΘΕΕ 02 - Σχολή Θετικών και Εφαρμοσμένων Επιστημών,
Πανεπιστημιούπολη
Education
1998-2004 PhD, The Rockefeller University. Morphogenetic Movements during the Xenopus Gastrulation and Development of Biocompatible Quantum Dots.
1994-1997 B.A. Biochemistry, Brandeis University. Summa Cum Laude and Highest Honors in Biochemistry
 
 
 

Εργαστήριο Μοριακής Εμβρυολογίας και Κυτταρικής Βιολογίας. Ο στόχος της ερευνητικής μας ομάδας είναι να κατανοήσουμε τους μοριακούς και κυτταρικούς μηχανισμούς οι οποίοι είναι υπεύθυνοι για την δημιουργία της τρισδιάστατης δομής των ιστών και τον σχηματισμό του σχεδίου του σώματος των σπονδυλωτών. Ταυτόχρονα το εργαστήριο μας με τις εφαρμογές νανοτεχνολογίας και συγκεκριμένα με την χρήση νανοκρυστάλλων (Quantum Dots) αναπτύσσει νέες μεθόδους απεικόνισης που επιτρέπουν τη μελέτη της μορφογένεσης στο οργανισμικό, κυτταρικό και μοριακό επίπεδο.

 

 

N Christodoulou, PA Skourides, Somitic mesoderm morphogenesis is necessary for neural tube closure during Xenopus development. Frontiers in Cell and Developmental Biology 10, 2496, 2023

M Chatzifrangkeskou, PA Skourides, The apical ciliary adhesion complex is established at the basal foot of motile cilia and depends on the microtubule network Scientific Reports 12 (1), 19028, 2022

Stathis Hadjidemetriou, Rania Hadjisavva, Andri Christodoulou, Ismini Papageorgiou, Ioanna Panayiotou, Paris A. Skourides, Spatiotemporal Identification of Cell Divisions Using Symmetry Properties in Time-Lapse Phase Contrast Microscopy, Symmetry 14 (9), 1802, 2022

R Hadjisavva, O Anastasiou, PS Ioannou, M Zheltkova, PA Skourides , Adherens junctions stimulate and spatially guide integrin activation and extracellular matrix deposition Cell Reports 40 (3), 111091, 2022

N Christodoulou, Paris A. Skourides, Distinct spatiotemporal contribution of morphogenetic events and mechanical tissue coupling during Xenopus neural tube closure. Development 149 (13), dev200358, 2022

Christina Demetriadou, Anastasia Raoukka, Evelina Charidemou, Constantine Mylonas, Christina Michael, Swati Parekh, Costas Koufaris, Paris A. Skourides, Panagiotis Papageorgis, Peter Tessarz, Antonis Kirmizis Histone N-terminal acetyltransferase NAA40 links one-carbon metabolism to chemoresistance. Oncogene 41 (4), 571-585, 2022

K Kaouri, N Christodoulou, A Chakraborty, PE Méndez, Paris A Skourides, Ricardo Ruiz-Baier A new mechanochemical model for apical constriction: Coupling calcium signalling and viscoelasticity Frontiers in Systems Biology, 38, 2022

Development of a Xenopus-based assay for high-throughput evaluation of mucociliary flow bioRxiv, 2022.07. 12.499724

Ioanna Antoniades, Maria Kyriakou, Anna Charalambous, Katerina Kalalidou, Andri Christodoulou, Maria Christoforou, Paris A Skourides. FAK displacement from focal adhesions: a promising strategy to target processes implicated in cancer progression and metastasis, Cell Communication and Signaling 19 (1), 1-22, 2021

E Michael, S Polydorides, VJ Promponas, P Skourides, G Archontis, Recognition of LD motifs by the focal adhesion targeting domains of focal adhesion kinase and proline‐rich tyrosine kinase 2‐beta: Insights from molecular dynamics simulations. Proteins: Structure, Function, and Bioinformatics 89 (1), 29-52, 2021

O Anastasiou, R Hadjisavva, PA Skourides, Mitotic cell responses to substrate topological cues are independent of the molecular nature of adhesion Science Signaling 13 (620), 2020 Cover article


K Kaouri, PK Maini, P Skourides, N Christodoulou, SJ Chapman
A simple mechanochemical model for calcium signalling in embryonic epithelial cells
Journal of Mathematical Biology 2019 pp 1–34
 
Antoniades I, Stylianou P, Christodoulou N, Skourides PA., Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells.
J Biol Chem. 2017 Jan 13;292(2):488-504.
 
 Petridou NI, Skourides PA. A ligand-independent integrin β1 mechanosensory complex guides spindle orientation.
Nat Commun. 2016 Mar 8;7:10899.
 
Christodoulou N, Skourides PA. Cell-Autonomous Ca(2+) Flashes Elicit Pulsed Contractions of an Apical Actin Network to Drive Apical Constriction during Neural Tube Closure.
Cell Rep. 2015 Dec 15;13(10):2189-202             f1000prime recommended article
 
Petridou NI, Skourides PA. FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis.
Nat Commun. 2014 Oct 24;5:5240.
 
Antoniades I, Stylianou P, Skourides PA, Making the connection: ciliary adhesion complexes anchor Basal bodies to the actin cytoskeleton.
Dev Cell. 2014 Jan 13;28(1):70-80.       f1000prime recommended article
 
Zanardelli S, Christodoulou N, Skourides PA.Calpain2 protease: A new member of the Wnt/Ca2+ pathway modulating convergent extension movements in Xenopus.
Dev Biol. 2013 Sep 26.
 
Petridou NI, Stylianou P, Skourides PA. A dominant-negative provides new insights into FAK regulation and function in early embryonic morphogenesis.
Development. 2013 Sep 18
 
Ioannou A, Santama N, Skourides PA.Xenopus laevis nucleotide binding protein 1 (xNubp1) is important for convergent extension movements and controls ciliogenesis via regulation of the actin cytoskeleton. Dev Biol. 2013 Aug 15;380(2):243-58.
 
Petridou NI, Stylianou P, Christodoulou N, Rhoads D, Guan JL, Skourides PA.Activation of endogenous FAK via expression of its amino terminal domain in Xenopus embryos. PLoS One. 2012;7(8):e42577.
 
Muro E, Fragola A, Pons T, Lequeux N, Ioannou A, Skourides P, Dubertret B.(2012) Comparing Intracellular Stability and Targeting of Sulfobetaine Quantum Dots with Other Surface Chemistries in Live Cells. Small. 2012 Feb 29. doi: 10.1002/smll.201101787
 
Charalambous A, Antoniades I, Christodoulou N, Skourides PA. (2011) Split-Inteins for Simultaneous, Site-Specific Conjugation of Quantum Dots to Multiple Protein Targets In vivo. J Nanobiotechnology Sep 15;9(1):37.
 
Eleonora Muro, Pierre Vermeulen, Andriani Ioannou, Paris Skourides, Benot Dubertret, Alexandra Fragola and Vincent LorietteSingle-Shot Optical Sectioning using Two-Color Probes in HiLo Fluorescence Microscopy Biophysical Journal Volume 100 May 2011 1–10
 
Charalambous A, Andreou M, Skourides PA.Intein-mediated site-specific conjugation of Quantum Dots to proteins in vivo. J Nanobiotechnology. 2009 Dec 10;7:9.
 
Stylianou P, Skourides PA.Imaging morphogenesis, in Xenopus with Quantum Dot nanocrystals. Mech Dev. 2009 Jul 30.
 
Yan CY, Skourides P, Chang C, Brivanlou A.Samba, a Xenopus hnRNP expressed in neural and neural crest tissues. Dev Dyn. 2009 Jan;238(1):204-9.
 
Demetriou MC, Stylianou P, Andreou M, Yiannikouri O, Tsaprailis G, Cress AE, Skourides P.Spatially and temporally regulated alpha6 integrin cleavage during Xenopus laevis development. Biochem Biophys Res Commun. 2007 Dec 18. 
 
Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A.In vivo imaging of quantum dots encapsulated in phospholipid micelles. Science. 2002 Nov 29;298(5599):1759-62.
 
Skourides P, Perera SA, Ren R.Polarized distribution of Bcr-Abl in migrating myeloid cells and co-localization of Bcr-Abl and its target proteins. Oncogene. 1999 Feb 4;18(5):1165-76.