101. Papaparaskeva G., M. Louca, C. Voutouri, T. Stylianopoulos and T. Krasia-Christoforou. Amalgamated Fiber/Hydrogel Composites Based on BIEE-Crosslinked Semi-Interpenetrating Polymer Networks and Electrospun Nanocomposite Fibrous Mats. (Under review)

100. Katsamba I., P. Evangelidis and T. Stylianopoulos. Biomechanical modelling of spinal tumor anisotropic growth. (Under review).

99. Gkretsi V., A. Stylianou, M. Kalli, M. Louca, C. Voutouri, A. Zaravinos and T. Stylianopoulos. Growth Differentiation Factor-15 silencing promotes Breast Cancer Cell invasion by Downregulating Focal Adhesion Genes. Anticancer Research (Accepted).

98. Petropoulou A., S. Kralj, X. Karagiorgis, I. Savva, E. Loizides, M. Panagi, T. Krasia-Christoforou and C. Riziotis. Multifunctional Gas and pH Fluorescent Sensors Based on Cellulose Acetate Electrospun Fibers Decorated with Rhodamine B-Functionalised Core-Shell Ferrous Nanoparticles. Scientific Reports [DOI: 10.1038/s41598-019-57291-0]


97. Mpekris F., C. Voutouri, J.W. Baish, D.G. Duda, L.L. Munn, T. Stylianopoulos, R.K. Jain. Combining microenvironment normalization strategies to improve cancer immunotherapy. PNAS [DOI: 10.1073/pnas.1919764117]

96. Martin J.D., H. Cabral, T. Stylianopoulos, and R.K. Jain. Improving cancer immunotherapy using nanomedicine: Progress, opportunities and challenges. Nature Reviews Clinical Oncology [DOI: 10.1038/s41571-019-0308-z]

95. Panagi M. , C. Voutouri, F. Mpekris, P. Papageorgis, M.R. Martin, J.D. Martin, P. Demetriou, C. Pierides, C. Polydorou, A. Stylianou, M. Louca, L. Koumas, P. Costeas, K. Kataoka and H. Cabral and T.  Stylianopoulos. TGF-β inhibition combined with cytotoxic nanomedicine normalizes triple negative breast cancer microenvironment towards anti-tumor immunity. Theranostics [DOI: 10.7150/thno.36936].

94. Kalli M., C. Voutouri, A. Minia, V. Pliaka, C. Fotis, L.G. Alexopoulos, and T. Stylianopoulos. Mechanical Compression inhibits the growth of brain cancer cell spheroids and regulates cell migration through MEK1/Erk1 pathway and GDF15 expression. Frontiers  [DOI: 10.3389/fonc.2019.00992].

93. Kontomaris S. V., A. Stylianou, K.S. Nikita, A. Malamou, T. Stylianopoulos. A simplified approach for the determination of fitting constants in Oliver – Pharr method regarding biological samples. Phys. Biol [DOI: 10.1088/1478-3975/ab252e].

92. Stylianou A., V. Gkretsi, M. Louca, L.C. Zacharia and T. Stylianopoulos. Collagen content and extracellular matrix cause cytoskeletal remodelling in pancreatic fibroblasts. Journal of the Royal Society Interface [DOI: 10.1098/rsif.2019.0226].

91. Gkretsi V., M. Kalli, C. Efstathiades, P. Papageorgis, V. Papanikolaou, L.C. Zacharia, A. Tsezou, E. Athanassiou, T. Stylianopoulos, Depletion of Ras Suppressor-1 (RSU-1) promotes cell invasion of breast cancer cells through a compensatory upregulation of a truncated isoform. Scientific Reports [DOI: 10.1038/s41598-019-46575-0]

90. Louca M., V. Gkretsi, and T. Stylianopoulos. Coordinated Expression of Ras Suppressor 1 (RSU-1) and Growth Differentiation Factor 15 (GDF15) Affects Glioma Cell Invasion. Cancers  [DOI: 10.3390/cancers11081159].

89. Martin J.D., M. Panagi, C. Wang, T.T. Khan, M.R. Martin, C. Voutouri, K. Toh, P. Papageorgis, F. Mpekris, C. Polydorou, G. Ishii, S. Takahashi, N. Gotohda, T. Suzuki, M.E. Wilhelm, V.A. Melo, S. Quader, J. Norimatsu, R.M. Lanning, M. Kojima, M.D. Stuber, T. Stylianopoulos, H. Cabral, and K. Kataoka and H. Cabra. The antiemetic dexamethasone increases nanocarrier delivery by normalizing the tumor microenvironment. ACS Nano [DOI: 10.1021/acsnano.8b07865].

88. Louca M., A. Stylianou, A. Minia, V. Pliaka, L.G. Alexopoulos V. Gkretsi and T. Stylianopoulos. Ras suppressor-1 (RSU-1) promotes cell invasion in aggressive glioma cells and inhibits it in non-aggressive cells through STAT6 phospho-regulation. Scientific Reports [DOI: 10.1038/s41598-019-44200-8]

87. Mascheroni P., C.L. Juan, M. Kalli, T. Stylianopoulos, M.H. Michael and H. Hatzikirou. On the impact of chemo-mechanically induced phenotypic transitions in gliomas. Cancers  [DOI: 10.3390/cancers11050716].

86. Demetriadou C., D. Pavlou, F. Mpekris, C. Achilleos, T. Stylianopoulos, A. Zaravinos, P. Papageorgis and A Kirmizis, Naa40 contributes to colorectal cancer growth by controlling PRMT5 expression. Cell Death & Disease [DOI: 10.1038/s41419-019-1487-3].


85. Voutouri C., N.D. Kirkpatrick, E. Chung, F. Mpekris, J.W. Baish, L.L. Munn, D. Fukumura, T. Stylianopoulos and R.K. Jain. Dynamics of vessel cooption in brain tumors revealed by integrative experimental and mathematical modeling studies. PNAS  [DOI: 10.1073/pnas.1818322116].

84. Zhao Y., J. Cao, A. Melamed, M. Worley, A. Gockley, D. Jones, H.T. Nia, Y. Zhang, T. Stylianopoulos, A.S. Kumar, F. Mpekris, M. Datta, Y. Sun, L. Wu, X. Gao, O. Yeku, M. del Carmen, D.R. Spriggs, R.K. Jain, and L. Xu. Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma. PNAS [DOI: 10.1073/pnas.1818357116].

83. Kalli M., F. Mpekris, K.C. Wong, M. Panagi, S. Ozturk, S. Thiagalingam, T. Stylianopoulos and P. Papageorgis. Activin A signaling regulates IL13Rα2 expression to promote breast cancer metastasis. Frontiers in Oncology (Accepted).

82. Gkretsi, V., Louca, M., Stylianou, A., George Minadakis, G., Spyrou, G.M and Stylianopoulos, T. Inhibition of breast cancer cell invasion by Ras suppressor-1 (RSU-1) silencing is reversed by Growth Differentiation Factor-15 (GDF-15). Journal of Molecular Sciences, 20 (1) [DOI: 10.3390/ijms20010163].

81. Kalli M., A. Minia, V. Pliaka, C. Fotis, L.G. Alexopoulos, T. Stylianopoulos, Solid stress-induced migration is mediated by GDF15 through Akt pathway activation in pancreatic cancer cells. Scientific Reports [DOI: 10.1038/s41598-018-37425-6].

80. Stylianou A., M. Lekka and T. Stylianopoulos. AFM Assessing of Nanomechanical FingerPrints for Cancer Early Diagnosis and Classification: from single cell to tissue level. Nanoscale [DOI: 10.1039/C8NR06146G].

79. Angeli S., K. E. Emblem, P. D. Tonnessen and T. Stylianopoulos. Towards patient-specific modeling of brain tumor growth and formation of secondary nodes guided by DTI-MRI. NeuroImage: Clinical [DOI: 10.1016/j.nicl.2018.08.032].

78. Vavourakis V., T. Stylianopoulos, P.A. Wijeratne. In-silico Dynamic Analysis of Cytotoxic Drug Administration to Solid Tumours: Effect of Binding Affinity and Vessel Permeability. PLoS Computational Biology 14(10):e1006460 [DOI: 10.1371/journal.pcbi.1006460].

77. Kontomaris S.V., A. Stylianou, A. Malamou and T. Stylianopoulos. A simplified AFM-based model for the calculation of the Young's modulus of cylindrical and spherical shaped samples. Materials Research Express [DOI: 10.1088/2053-1591/aad2c9]

76. Kitiri E.N., C.K. Varnava, C.S. Patrickios, Voutouri, T. Stylianopoulos, M. Gradzielski and I. Hoffmann. Double-networks Based on Interconnected Amphiphilic “In-out” Star First Polymer Conetworks Prepared by RAFT Polymerization. Journal of Polymer Science, Part A: Polymer Chemistry. [DOI:](Accepted)

75. Stylianou A., V. Gkretsi, and T. Stylianopoulos. Atomic Force Microscopy Nano-Characterization of 3D Collagen Gels with Tunable Stiffness. MethodsX  5:503-513 [DOI: 10.1016/j.mex.2018.05.009]

74. Papaparaskeva G., C. Voutouri, V. Gkretsi, M. Achilleos, T. Stylianopoulos and T. Krasia-Christoforou. Tuning the Mechanical Properties of BIEE-crosslinked Semi-Interpenetrating, Double-Hydrophilic Hydrogels. Macromolecular Materials and Engineering [DOI: 10.1002/mame201700643].

73. Gkretsi V., and T. Stylianopoulos. Cell adhesion and matrix stiffness: coordinating cancer cell invasion and metastasis. Frontiers in Oncology  8:145 [DOI: 10.3389/fonc.2018.00145].

72. Mpekris F., C. Voutouri, P. Papageorgis and T. Stylianopoulos. Stress alleviation strategy in cancer treatment: Insights from a mathematical model.  Z Angew Math Mech. 2018;1–12 [DOI: 10.1002/zamm.201700270].

71. Stylianopoulos T., L.L. Munn, and R.K. Jain. Reengineering the physical microenvironment of tumors to improve drug delivery and efficacy: From math modeling to bench to bedside. Trends in Cancer  4(4):292-319 [DOI: 10.1016/j.trecan.2018.02.005].

70. Voutouri C. and T. Stylianopoulos. Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness. PLoS One 13(3): e0193801 [DOI: 10.1371/journal.pone.0193801].

69. Kalli M. and T. Stylianopoulos. Defining the role of solid stress and matrix stiffness in cancer cell proliferation and metastasis. Frontiers in Oncology  8:55 [DOI: 10.3389/fonc.2018.00055].

68. Stylianou A., V. Gkretsi and T. Stylianopoulos. Transforming Growth Factor-β modulates Pancreatic Cancer Associated Fibroblasts cell shape, stiffness and invasion. BBA  1862(7):1537-1546 [DOI: 10.1016/j.bbagen.2018.02.009].

67. Kalli M., P. Papageorgis, V. Gkretsi and T. Stylianopoulos. Solid stress facilitates fibroblasts activation to promote pancreatic cancer cell migration. Annals of Biomedical Engineering. 46(5):657-669 [DOI: 10.1007/s10439-018-1997-7].

66. Zacharia LC, T. Stylianopoulos, and V. Gkretsi. Ras Suppressor-1 (RSU-1) in cancer cell metastasis: friend or foe? Critical Reviews in Oncogenesis. 22(3-4):249-253 [DOI: 10.1615/CritRevOncog.2018024231].



65. Stylianou A., Gkretsi V., Patrickios C.S., Stylianopoulos T. Exploring the Nano-Surface of Collagenous and Other Fibrotic Tissues with AFM. In: Rittié L. (eds) Fibrosis. Methods in Molecular Biology, vol 1627. Humana Press, New York, NY [DOI: 0.1007/978-1-4939-7113-8_29]

64. P.A. Wijeratne, J.H. Hipwell, D.J. Hawkes, T. Stylianopoulos and V. Vavourakis. Multiscale biphasic modelling of peritumoural collagen microstructure: the effect of tumor growth on permeability and fluid flow. PlosOne 12(9): e0184511. [DOI: 10.1371/journal.pone.0184511]

63. Gkretsi V., L.C. Zacharia, and T. Stylianopoulos. Targeting inflammation to improve tumor drug delivery. Trends in Cancer 3(9): 621-630. [DOI: 10.1016/j.trecan.2017.07.006]

62. Mpekris F., P. Papageorgis, C. Polydorou, C. Voutouri, M. Kalli, A.P. Pirentis and T. Stylianopoulos. Sonic-hedgehog pathway inhibition normalizes desmoplastic tumor microenvironment to improve chemo- and nanotherapy. Journal of Controlled Release 261(10): 105-112. [DOI: 10.1016/j.jconrel.2017.06.022]

61. Papageorgis P., C. Polydorou, F. Mpekris, C. Voutouri, E. Agathokleous, C. P. Kapnissi-Christodoulou, and T. Stylianopoulos. Tranilast-induced stress alleviation in solid tumors improves the efficacy of chemo- and nanotherapeutics in a size-independent manner. Scientific Reports 7:46140. [DOI: 10.1038/srep46140]

60. Gkretsi V., A. Stylianou, M. Louca, and T. Stylianopoulos. Identification of Ras suppressor-1 (RSU-1) as a potential breast cancer metastasis biomarker using a three-dimensional in vitro approach. Oncotarget 8(16):27364-27379. [DOI: 10.18632/oncotarget.16062]

59. Angeli S., and T. Stylianopoulos. Experimental measurements and mathematical modeling towards quantification of brain swelling stress. Journal of Biomechanics 56:42-47. [DOI: 10.1016/j.jbiomech.2017.02.028]

58. Polydorou C., F. Mpekris, P. Papageorgis, C. Voutouri, and T. Stylianopoulos. Pirfenidone normalizes the tumor microenvironment to improve chemotherapy. Oncotarget 8(15):24506-24517.[DOI: 10.18632/oncotarget.15534]

57. Gkretsi V., A. Stylianou, and T. Stylianopoulos. Vasodilator-Stimulated Phosphoprotein (VASP) depletion from breast cancer MDA-MB-231 cells inhibits tumor spheroid invasion through downregulation of Migfilin, β-catenin and urokinase-plasminogen activator (uPa). Experimental Cell Research 352(2): 281-292. [DOI: 10.1016/j.yexcr.2017.02.019]

56. Mpekris F., J.W. Baish, T. Stylianopoulos, and R.K. Jain. Role of vascular normalization in benefit from metronomic chemotherapy. Proceedings of the National Academy of Sciences USA 114(8): 1994-1999. [DOI: 10.1073/pnas.1700340114]

55. Ambrosi D., S. Pezzuto, D. Riccobelli, T. Stylianopoulos, and P. Ciarletta. Solid tumors are poroelastic solid with chemo-mechanical feedback on growth. Journal of Elasticity 129(1-2):107-124 [DOI: 10.1007/s10659-016-9619-9]

54. Vavourakis V., P.A. Wijeratne, R. Shipley, M. Loizidou, T. Stylianopoulos, and D.J. Hawkes. A validated multiscale in-silico model for mechano-sensitive tumour angiogenesis and growth. PLoS Computational Biology 13(1): e1005259. [DOI: 10.1371/journal.pcbi.1005259]

53. Stylianopoulos T. The solid mechanics of cancer and strategies for improved therapy. Journal of Biomechanical Engineering 139(2): 021004. [DOI: 10.1115/1.4034991]

52. Kitiri E., C. Patrickios, C. Voutouri, T. Stylianopoulos, I. Hoffmann, R. Schweins, and M. Gradzielski. Synthesis and characterization of double-networks based on pH-responsive, amphiphilic "core-first" star first polymer conetworks prepared by sequential RAFT polymerization. Polymer Chemistry 8(1): 245-259. [DOI: 10.1039/C6PY01340F]



51. Alfonso J.C.L., A. Köhn-Luque, T. Stylianopoulos, F. Feuerhake, A. Deutsch, and H. Hatzikirou. Why one-size-fits-all vaso-modulatory interventions fail to control glioma invasion: in silico sights. Scientific Reports 6: 37283. [DOI: 10.1038/srep37283]

50. Voutouri C., C. Polydorou, P. Papageorgis, V. Gkretsi, and T. Stylianopoulos. Hyaluronan-derived swelling of solid tumours, the contribution of collagen and cancer cells, and implications for cancer therapy. Neoplasia 18(12): 732-741. [DOI: 10.1016/j.neo.2016.10.001]

49. Wijeratne P.A., V. Vavourakis, J.H. Hipwell, C. Voutouri, P. Papageorgis, T. Stylianopoulos, A. Evans, and D.J. Hawkes. Multiscale modelling of solid tumour growth: the effect of collagen micromechanics. Biomechanics and Modeling in Mechanobiology 15(5): 1079-1090. [DOI: 10.1007/s10237-015-0745-2]

48. Achilleos M., F. Mpekris, T. Stylianopoulos, and T. Krasia-Christoforou. Structurally-defined semi-interpenetrating amphiphilic polymer networks with tunable and predictable mechanical response. RSC Advances 6(49): 43278-43283. [DOI: 10.1039/C6RA07376J]

47. Angeli S., and T. Stylianopoulos. Biphasic modeling of brain tumor biomechanics and response to radiation treatment. Journal of Biomechanics 49(9): 1524-1531. [DOI: 10.1016/j.jbiomech.2016.03.029]

46. Stylianou A., and T. Stylianopoulos. Atomic force microscopy probing of cancer cells and tumor microenvironment components. BioNanoScience 6(1): 33-46. [DOI: 10.1007/s12668-015-0187-4]

45. Stylianopoulos T. Intelligent drug delivery systems for the treatment of solid tumors. European Journal of Nanomedicine 8(1): 9-16. [DOI: 10.1515/ejnm-2015-0041]



44. Savva I., E. Evaggelou, G. Papaparaskeva, T. Leontiou, T. Stylianopoulos, F. Mpekris, K. Stylianou, and T. Krasia-Christoforou. Alignment of electrospun polymer fibers using a concave collector. RSC Advances 5(126): 104400-104407. [DOI: 10.1039/C5RA20429A]

43. Gkretsi V., A. Stylianou, P. Papageorgis, C. Polydorou, and T. Stylianopoulos T. Remodeling components of the tumor microenvironment to enhance cancer therapy. Frontiers in Oncology 5: 214. [DOI: 10.3389/fonc.2015.00214]

42. Kepola E.J, E. Loizou, C.S. Patrickios, E. Leontidis, C. Voutouri, T. Stylianopoulos, R. Schweins, M. Gradzielski, C. Krumm, J.C. Tiller, M. Kushnir, and C. Wesdemiotis. Amphiphilic polymer conetworks based on end-linked "core-first" star block copolymers: structure formation with long-range order. ACS Macro Letters 4(9): 1163-1168 (2015) [DOI: 10.1021/acsmacrolett.5b00608]

41. Stylianopoulos T., and R.K. Jain. Design considerations for nanotherapeutics in oncology. Nanomedicine: Nanotechnology, Biology and Medicine 11(8): 1893-1907. [DOI: 10.1016/j.nano.2015.07.015]

40. Papaphilippou P.Ch., I. Vyrides, F. Mpekris, T. Stylianopoulos, C.A. Papatryphonos, C.R. Theocharis, and T. Krasia-Christoforou. Evaluation of novel, cationic electrospun microfibrous membranes as adsorbents in bacteria removal. RSC Advances 5(83): 67617-67629. [DOI: 10.1039/C5RA11406C]

39. Duda D.G., R.S. Heist, D.V. Sahani, T. Stylianopoulos, J.A. Engelman, and R.K. Jain. Reply to Ciccolini et al.: Using mathematical modeling to predict response to antiangiogenic therapy in cancer patients. Proceedings of the National Academy of Sciences USA 112(27): E3454. [DOI: 10.1073/pnas.1507225112]

38. Mpekris F., S. Angeli, A.P. Pirentis, and T. Stylianopoulos. Stress-mediated progression of solid tumors: effect of mechanical stress on tissue oxygenation, cancer cell proliferation and drug delivery. Biomechanics and Modeling in Mechanobiology 14(6): 1391-1402. [DOI: 10.1007/s10237-015-0682-0]

37. Pirentis A.P., C. Polydorou, P. Papageorgis, C. Voutouri, F. Mpekris, and T. Stylianopoulos. Remodelling of extracellular matrix due to solid stress accumulation during tumour growth. Connective Tissue Research 56(5): 345-354. [DOI: 10.3109/03008207.2015.1047929]

36. Stylianopoulos T., E.-A. Economides, J.W. Baish, D. Fukumura, and R.K. Jain. Towards optimal design of cancer nanomedicines: multi-stage nanoparticles for the treatment of solid tumors. Annals of Biomedical Engineering 43(9): 2291-2300. [DOI: 10.1007/s10439-015-1276-9]

35. Mpekris F., M. Achilleos, E. Vasile, E. Vasile, T. Krasia-Christoforou, and T. Stylianopoulos. Mechanical properties of structurally-defined magnetoactive polymer (co)networks. RSC Advances 5(26): 20011-20019. [DOI: 10.1039/C4RA16260A]

34. Papageorgis P., and T. Stylianopoulos. Role of TGFβ in regulation of the tumor microenvironment and drug delivery. International Journal of Oncology 46(3): 933-943. [DOI: 10.3892/ijo.2015.2816]



33. Voutouri C., and T. Stylianopoulos. Evolution of osmotic pressure in solid tumors. Journal of Biomechanics 47(14): 3441-3447. [DOI: 10.1016/j.jbiomech.2014.09.019]

32. Voutouri C., F. Mpekris, P. Papageorgis, A.D. Odysseos, and T. Stylianopoulos. The role of constitutive behavior and tumor-host mechanical interactions in the state of stress and growth of solid tumors. PLoS One 9(8): e104717. [DOI: 10.1371/journal.pone.0104717]

31. Chauhan V.P., Y. Boucher, C.R. Ferrone, S. Roberge, J.D. Martin, T. Stylianopoulos, N. Bardeesy, R.A. DePinho, T.P. Padera, L.L. Munn, and R.K. Jain. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell 26(1): 14-15. [DOI: 10.1016/j.ccr.2014.06.003]

30. Jain R.K., J.D. Martin, and T. Stylianopoulos. The role of mechanical forces in tumor progression and therapy. Annual Reviews of Biomedical Engineering 16: 321-346. [DOI: 10.1146/annurev-bioeng-071813-105259]

29. Achilleos A., C. Loizidis, M. Hadjiandreou, T. Stylianopoulos, and G. Mitsis. Multiprocessing linear dynamics modeling for personalized tumor growth prediction. Annals of Biomedical Engineering 42(5): 1095-1111. [DOI: 10.1007/s10439-014-0975-y]



28. Stylianopoulos T., and R.K. Jain. Combining two strategies to improve perfusion and drug delivery in solid tumors. Proceedings of the National Academy of Sciences USA 110(46): 18632-18637. [DOI: 10.1073/pnas.1318415110]

27. Huang Y., T. Stylianopoulos, D. Duda, D. Fukumura, and R.K. Jain. Benefits of vascular normalization are dose and time dependent. Cancer Research 73(23): 7144-7146. [DOI: 10.1158/0008-5472.CAN-13-1989]

26. Chauhan V.P., J.D. Martin, H. Liu, D.A. Lacorre, S.R. Jain, S.V. Kozin, T. Stylianopoulos, A.S. Mousa, X. Han, P. Adstamongkonkul, Z. Popovic, P. Huang, M.G. Bawendi, Y. Boucher and R.K. Jain. Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumor blood vessels. Nature Communications 4: 2516. [DOI: 10.1038/ncomms3516]

25. Stylianopoulos T., J.D. Martin, M. Snuderl, F. Mpekris, S. Jain, and R.K. Jain. Coevolution of solid stress and interstitial fluid pressure in tumor during progression: Implications for vascular collapse. Cancer Research 73(13): 3833-3841. [DOI: 10.1158/0008-5472.CAN-12-4521]

24. Stylianopoulos T. EPR-effect: utilizing size-dependent nanoparticle delivery to solid tumors. Therapeutic delivery 4.4: 421-423. [DOI: 10.4155/tde.13.8]

23. Stylianopoulos T., K. Soteriou, D. Fukumura, and R.K. Jain. Cationic nanoparticles have superior transvascular flux in solid tumors: Insights from a mathematical model. Annals of Biomedical Engineering 41(1): 68-77. [DOI: 10.1007/s10439-012-0630-4]



22. Stylianopoulos T., M. Kokonou, S. Michael, A. Tryfonos, C. Rebholz, A.D. Odysseos, and D. Doumanidis. Tensile mechanical properties and hydraulic permeabilities of electrospun cellulose acetate fiber meshes. Journal of Biomedical Materials Research - Part B Applied Biomaterials 100(8): 2222-2230. [DOI: 10.1002/jbm.b.32791]

21. Stylianopoulos T., J.D. Martin, V.P. Chauhan, S.R. Jain, B. Diop-Frimpong, B. Smith, C.R. Ferrone, F. Hornicek, Y. Boucher, L.L. Munn, and R.K. Jain. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proceedings of the National Academy of Sciences USA 109(38): 15101-15108. [DOI: 10.1073/pnas.1213353109]

20. Chauhan V.P., T. Stylianopoulos, J.D. Martin, Z. Popovic, W.S. Kamoun, M.G. Bawendi, D. Fukumura, and R.K. Jain. Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner. Nature Nanotechnology 7: 383-388. [DOI: 10.1038/nnano.2012.45]

19. Stylianopoulos T., C. Wong, M.G. Bawendi, R.K. Jain, and D. Fukumura. Multistage nanoparticles for improved delivery into tumor tissue. Methods in Enzymology 508: 109-130. [DOI: 10.1016/B978-0-12-391860-4.00006-9]


PI's pre-CBL publications



18. Chauhan V.P., T. Stylianopoulos, Y. Boucher, and R.K. Jain. Delivering of molecular and nanoscale medicine to tumors: transport barriers and strategies. Annual Reviews of Chemical and Biomolecular Engineering 2: 281-298. [DOI: 10.1146/annurev-chembioeng-061010-114300]

17. Wong C.R., T. Stylianopoulos, J. Cui, J. Martin, V.P. Chauhan, W. Jiang, Z. Popovic, R.K. Jain, M.G. Bawendi, and D. Fukumura. Multistage nanoparticle delivery system for deep penetration into tumor tissue. Proceedings of the National Academy of Sciences USA 108(6): 2426-2431. [DOI: 10.1073/pnas.1018382108]

16. Baish J.W., T. Stylianopoulos, R.M. Lanning, W. Kamoun, L.L. Munn, D. Fukumura, and R.K. Jain. Scaling rules for diffusive drug delivery in tumor and normal tissues. Proceedings of the National Academy of Sciences USA 108(5): 1799-1803. [DOI: 10.1073/pnas.1018154108]



15. Stylianopoulos T., B. Diop-Frimpong, L.L. Munn, and R.K. Jain. Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation. Biophysical Journal 99(10): 3119-3128. [DOI: 10.1016/j.bpj.2010.08.065]

14. Jain R.K., and T. Stylianopoulos. Delivering nanomedicine to solid tumors. Nature Reviews Clinical Oncology 7(11): 653-664. [DOI: 10.1038/nrclinonc.2010.139]

13. Stylianopoulos T., M.Z. Poh, N. Insin, L.L. Munn, D. Fukumura, M. Bawendi, and R.K. Jain. Diffusion of particles in the extracellular matrix: effect of repulsive electrostatic interactions. Biophysical Journal 99(5): 1342-1349. [DOI: 10.1016/j.bpj.2010.06.016]



12. Vakoc V.J., R.M. Lanning, J.A. Tyrrell, T.P. Padera, L. Bartlett, T. Stylianopoulos, L.L. Munn, G.J. Tearney, D. Fukumura, R.K. Jain, and B.E. Bouma. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nature Medicine 15(10): 1219-1223. [DOI: 10.1038/nm.1971]

11. Mok W., T. Stylianopoulos, Y. Boucher, and R.K. Jain. Mathematical modeling of herpes simplex virus distribution in solid tumors: implications for cancer gene therapy. Clinical Cancer Research 15(7): 2352-2360. [DOI: 10.1158/1078-0432.CCR-08-2082]

10. Sander E.A., T. Stylianopoulos, R.T. Tranquillo, and V.H. Barocas. Image-based multi-scale modeling predicts tissue-level and network-level fiber reorganization in stretched cell-compacted collagen gels. Proceedings of the National Academy of Sciences USA 106(42): 17675-17680. [DOI: 10.1073/pnas.0903716106]

9.  Sander E.A., T. Stylianopoulos, R.T. Tranquillo, and V.H. Barocas. Image-based biomechanics of collagen-based tissue equivalents. IEEE Engineering in Medicine and Biology 28(3): 10-18. [DOI: 10.1109/MEMB.2009.932486]

8.  Luo X., T. Stylianopoulos,V.H. Barocas, and M.S. Shephard. Multiscale computation for bioartificial soft tissues with complex geometries. Journal of Engineering with Computers 25(1): 87-95. [DOI: 10.1007/s00366-008-0111-4]



7.  Stylianopoulos T., A. Yeckel, J.J. Derby, X. Luo, M.S. Shephard, E.A. Sander, and V.H. Barocas. Permeability calculations in three-dimensional isotropic and oriented fiber Networks. Physics of Fluids 20(12): 123601. [DOI: 10.1063/1.3021477]

6.  Stylianopoulos T.,C.A. Bashur, A.S. Goldstein, S.A. Guelcher, and V.H. Barocas. Computational predictions of the tensile properties of electrospun fiber meshes: effect of fiber diameter and fiber orientation. Journal of the Mechanical Behavior of Biomedical Materials 1(4): 326-335. [DOI: 10.1016/j.jmbbm.2008.01.003]

5.  Chandran P.L., T. Stylianopoulos,and V.H. Barocas. Microstructure based, multiscale modeling for the mechanical behavior of hydrated fiber networks. SIAM Multiscale Modeling and Simulation 7(1): 22-43. [DOI: 10.1137/070689504]

4.  Stylianopoulos T., A. Aksan, and V.H. Barocas. A structure-based, kinetic model of soft tissue thermomechanics. Biophysical Journal 94(3): 717-725. [DOI: 10.1529/biophysj.107.111716]



3.  Stylianopoulos T., and V.H. Barocas. Multiscale structure-based modeling for the elastic mechanical behavior of arterial walls. Journal of Biomechanical Engineering 129(4): 611-618. [DOI: 10.1115/1.2746387]

2.  Stylianopoulos T., and V.H. Barocas. Volume averaging theory for the study of the mechanics of collagen networks. Computer Methods in Applied Mechanics and Engineering 196(31-32): 2981-2990. [DOI: 10.1016/j.cma.2006.06.019]



1.  Oyen M.L., R.F. Cook, T. Stylianopoulos, V.H. Barocas, S.E. Calvin, and D.V. Landers. Uniaxial and biaxial mechanical behavior of human amnion. Journal of Materials Research 20(11): 2902-2909. [DOI: 10.1557/JMR.2005.0382]