Michalis (Mike) Averkiou is associate professor at the Department of Mechanical and Manufacturing Engineering of the University of Cyprus since 2005 and the recipient of the Marie Curie Chair of Excellence of the European Commission (2006-2009). He received a BS, an MS and a PhD in 1987, 1989 and 1994, respectively, all in Mechanical Engineering with specialization in Nonlinear Acoustics/Biomedical Ultrasound, from the University of Texas at Austin. He was a Postdoctoral Fellow at the Applied Physics Laboratory of the Univ. of Washington from 1994 to 1996 and worked on lithotripsy, bubble dynamics, and therapeutic ultrasound. He joined Philips Medical Systems (1996-2005), and worked on diagnostic ultrasound imaging and specifically tissue harmonic imaging, and ultrasound contrast agents. He is also an Adjunct Research Professor at the University of Washington (1996-present). He has authored and co-authored over 40 journal articles and conference proceedings, and 3 book chapters. He holds 32 U.S. and international patents on diagnostic and therapeutic applications of ultrasound.

His research interests are in the areas of diagnostic ultrasound, angiogenesis quantification, image guided intervention, and therapeutic applications of ultrasound (thermal ablation, ultrasound-enhanced drug delivery). He is particularly interested in microbubble ultrasound contrast agents and their applications in oncology, including imaging and quantification of tumor angiogenesis.

Journal Papers (selection)
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1. T. Gauthier, M. Averkiou, E. Leen, “Perfusion quantification using dynamic contrast-enhanced ultrasound: The impact of dynamic range and gain on time–intensity curves,” Ultrasonics 51(1), 102-106, 2011. (Epub 2010 Jun 25)
2. V. Sboros, M. Averkiou, M. Lampaskis, J. Docherty and A. McNeilly, “Imaging of the ovine corpus luteum microcirculation with contrast ultrasound,” Ultrasound in Med. & Biol., 37(1), 59-68, 2011.
3. C. Strouthos, M. Lampaskis, V. Sboros, A. McNeilly, and M. Averkiou, “Indicator Dilution Models for the Quantification of Microvascular Blood Flow with Bolus Administration of Ultrasound Contrast,” IEEE Trans. Ultrason., Ferroelect., Freq., Contr., 57(6), 1296-1310, 2010.
4. M. Lampaskis and M. Averkiou, “Investigation of the relationship of nonlinear backscattered ultrasound intensity with microbubble concentration at low MI,” Ultrasound in Med. & Biol., 36(2), 306-312, 2010.
5. M. Averkiou, M. Lampaskis, K. Kyriakopoulou, D. Skarlos, G. Klouvas, C. Strouthos, E. Leen, “Quantification of Tumor Microvascularity with Respiratory Gated Contrast Enhanced Ultrasound for Monitoring Therapy,” Ultrasound in Med. & Biol. 36(1), 68-77, 2010.
6. J. Powers, M. Averkiou, and M. Bruce, “Principles of Cerebral Ultrasound Contrast Imaging,” Bubbles Ultrasound and Cerebrovascular Disease edited by Stephen Meairs, Cerebrovascular Diseases, Vol. 27, Suppl. 2, 14-24, 2009
7. E. Leen, S. Kumar, S. A Khan, G. Low, K. Oon Ong, P. Tait, and M. Averkiou, “Contrast-enhanced 3D ultrasound in the radiofrequency ablation of liver tumors,” World J Gastroenterol, 15(3), 289-299, 2009.
8. D. L. Miller, M. A. Averkiou, A. A. Brayman, E. C. Everbach, C. K. Holland, J. H. Wible, Jr, and J. Wu, “Bioeffects Considerations for Diagnostic Ultrasound Contrast Agents,” J Ultrasound Med 27, 611–632, 2008.
9. V. A. Khokhlova, A. E. Ponomarev, M. A. Averkiou, and L. A. Crum, “Nonlinear pulsed ultrasound beams radiated by rectangular focused diagnostic transducers,” Ac. Physics 52(4), 560-570, 2006.
10. M. Bruce, M. A. Averkiou, K. Tiemann, J. Powers, and K. Beech, “Vascualr and macro-vascular blood flow imaging with ultrasound contrast agents,” Ultrasound in Med. & Biol. 30(6), 735-743, 2004.
11. M. Averkiou, J. Powers, D. Skyba, M. Bruce, and S. Jensen, “Ultrasound contrast imaging research,” Ultrasound Quarterly, 19(1), 27-37, 2003.
12. P. N. Burns, D, Hope Simpson, M. Averkiou, “Nonlinear imaging,” Ultras Med. & Biol. 26(1), S19-S22, 2000.
13. M. A. Averkiou and R. O. Cleveland, “Modeling of an electrohydraulic lithotripter with the KZK equation,” J. Acoust. Soc. Am. 106(1), 102-112, 1999.
14. H. Becher, K. Tiemann, C. Pohl, N. C. Nanda, M. A. Averkiou, J. E. Powers, and B. Lüderitz, “Improvement in endocardial border delineation using tissue harmonic imaging,” Echocardiography 15, 511-517, 1998.
15. M. A. Averkiou and M. F. Hamilton, “Nonlinear distortion of short pulses radiated by plane and focused circular pistons,” J. Acoust. Soc. Am. 102(5), 2539-2548, 1997.
16. M. A. Averkiou and M. F. Hamilton, “Measurements of harmonic generation in a focused sound beam of finite amplitude,” J. Acoust. Soc. Am. 98(6), 3439-3442, 1995.
17. M. A. Averkiou, Y. S. Lee, and M. F. Hamilton, “Self demodulation of amplitude and frequency modulated pulses in a viscous fluid,” J. Acoust. Soc. Am. 94, 2876-2883, 1993.


Book Chapters
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1. M. A. Averkiou and L. A. Crum, “Cavitation: Its role in stone comminution and renal injury,” in Topics in clinical Urology: New Developments in the management of urolithiasis, J. Lingeman & G. M. Preminger, eds, New York, pp.21-40, 1995.
2. M. Averkiou, “Tissue harmonic ultrasonic imaging,” in Optical and acoustical imaging of biological media, C. R. Acad. Sci. Paris, Applied Physics(Biophysics), t. 2, Serie IV, Elsevier, Paris, pp.1139-1151, 2001.
3. G. A. Schwartz and M. A. Averkiou, “Future Directions -- New Developments in Ultrasound,” in Imaging in Oncological Urology, J. de la Rosette, M. Harisinghani, M. Manyak, and H. Wijkstra, eds, Springer-Verlag, London, 2008.

Patents (selection out of 32)
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1. M. A. Averkiou, M. F. Bruce, and J. E. Powers, “Ultrasonic diagnostic imaging with contrast agents”, United States Patent 5,833,613, Nov. 10, 1998.
2. M. A. Averkiou, “Ultrasonic transmit pulses for nonlinear ultrasonic imaging” US Pat. 5,980,457, Nov. 9, 1999.
3. M. A. Averkiou, J. E. Powers, M. Bruce, D. M. Skyba, “Realtime ultrasonic imaging of perfusion using ultrasonic contrast agents,” United States Patent 6,171,246, Jan. 9, 2001.
4. M. A. Averkiou, J. E. Powers, P. N. Burns, D. N. Roundhill, J. J. Hwang, J. D. Wiggins, “Ultrasonic tissue harmonic imaging,” United States Patent 6,251,074, Jun. 6, 2001.
5. J. E. Powers, M. A. Averkiou, M. Bruce, D. M. Skyba, R. R. Entrekin, J. D. Fraser, C. R. Cooley, B. S. Robinson, D. N. Roundhill, G. A. Schwartz, and P. R. Pesque, “Ultrasonic diagnostic imaging of the coronary arteries,” US Patent 6,468,216, Oct. 22, 2002.
6. M. A. Averkiou, M. Bruce, and J. E. Powers, “Ultrasonic perfusion measurement using contrast agents,” United States Patent 6,540,684, Apr. 1, 2003.

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