Profile
Diploma in Chemical Engineering, 2003
National Technical University of Athens, Greece
PhD in Chemical Engineering, 2008
University of Minnesota, USA
Postdoctoral training,
Department of Radiation Oncology
Massachusetts General Hospital / Harvard Medical School
Triantafyllos received a Diploma in Chemical Engineering from National Technical University of Athens, Greece (GPA: 9.34/10) in 2003. The same year he joined the Chemical Engineering graduate program at the University of Minnesota, USA to pursue his doctoral studies. He worked with Professor Victor Barocas on modeling the mechanical response of native and bioartificial tissues. During his doctoral studies, Triantafyllos was elected twice top doctoral student of the department. After the completion of his PhD., in May 2008, Triantafyllos worked as a postdoctoral fellow in Dr. Rakesh Jain's lab in the department of Radiation Oncology at Harvard Medical School and Massachusetts General Hospital, USA. In Dr. Jain's lab he performed research in a mixture of experimental and computational problems for optimizing the delivery of nanomedicine to solid tumors. In September 2010, Triantafyllos joined the faculty of the Mechanical and Manufacturing Engineering department at the University of Cyprus. He also holds a visiting research fellow position at Harvard Medical School and at the Minnesota Supercomputing Institute of the University of Minnesota.
Triantafyllos has published over twenty publications in peer-review journals including three in Nature (Nature Medicine (ISI impact factor: 25.43), Nature Nanotechnology (ISI impact factor: 30.31), Nature Reviews Clinical Oncology (ISI impact factor: 10.78)) and three in the Proceedings of the National Academy of Science (ISI impact factor: 9.75). His work has been highlighted by Nature, Nature Materials, PNAS, and the American Association of Cancer Research. Two of his recent publications were selected by the "Faculty of 1000" among the top 2% articles in biology and medicine. His research work has received more than 400 citations.
Triantafyllos is a member of the American Institute of Chemical Engineers, the European Foundation of Clinical Nanomedicine, the European Society of Biomechanics and the Greek Association of Computational Mechanics.
Research Interests
Tumor biology and mathematical modeling. Use of experimental imaging techniques (multi-photon and confocal microscopy)and mathematical modeling to optimize the delivery of nanomedicine to solid tumors.
Computational biomechanics. Multiscale modeling for the study of the mechanical behavior of soft biological tissues and biomedical materials.
Selected Publications
V. P. Chauhan*, T. Stylianopoulos*, J. D. Martin, Z. Popovic, W. S. Kamoun, M. G. Bawendi, D. Fukumura, and R. K. Jain, "Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner", Nature Nanotechnology, Advanced online publication (8 April 2012). *Equal contribution
C. R. Wong, T. Stylianopoulos, J. Cui, J. Martin, V. P. Chauhan, W. Jiang, Z. Popovic, R. K. Jain, M. G. Bawendi and D. Fukumura "Multistage nanoparticle delivery system for deep penetration into tumor tissue", PNAS, 108(6), pp. 2426-2431, 2011.
J. W. Baish, T. Stylianopoulos, R. M. Lanning, W. Kamoun, L. L. Munn, D. Fukumura, R. K. Jain, “Scaling rules for diffusive drug delivery in tumor and normal tissues”, PNAS, 108(5), pp.1799-1803, 2011.
R. K. Jain and T. Stylianopoulos, "Delivering Nanomedicine to Solid Tumors", Nature Reviews Clinical Oncology, 7, pp. 653-664, 2010.
T. Stylianopoulos, B. Diop-Frimpong, L. L. Munn, and R. K. Jain, "Diffusion Anisotropy in Collagen Gels and Tumors: The Effect of Fiber Network Orientation", Biophysical J., 99(10), pp. 3119-3128, 2010.
T. Stylianopoulos, M. Z. Poh, N. Insin, L. L. Munn, D. Fukumura, M. Bawendi, R. K. Jain, “Diffusion of Particles in the Extracellular Matrix:The Effect of Repulsive Electrostatic Interactions”, Biophysical J., 99(5), pp. 1342-1349, 2010.
E. A. Sander, T. Stylianopoulos, R. T. Tranquillo, and V. H. Barocas, “Image-based Multi-scale Modeling Predicts Tissue-level and Network-level Fiber Reorganization in Stretched Cell-compacted Collagen Gels”, PNAS, 106(42), pp. 17675-17680, 2009.
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