New study from the Cell ad Developmental Biology laboratory shows that that c-Jun N-terminal kinase (JNK) is involved in ciliogenesis.

Dr. Maria Chatzifrangkeskou just published a new article in the Journal of Cell Biology. Maria, using Xenopus embryos and cultured cells showed that JNK is found at the base of motile and primary cilia, in association with the basal bodies. In multiciliated cells, JNK is involved in ciliogenesis and the ciliary function through the regulation of the actin networks of multiciliated cells and the establishment of the intraflagellar transport-B core complex. JNK is implicated in the development of diabetes, neurodegeneration, and liver disease, all of which have been linked to ciliary dysfunction. This work raises the possibility that the involvement of JNK in disease may in part stem from its role in ciliogenesis and ciliary function.

The full manuscript can be found here: https://rupress.org/jcb/article/222/11/e202303052/276339/JNK-regulates-ciliogenesis-through-the