{"id":1633,"date":"2023-12-19T05:48:30","date_gmt":"2023-12-19T03:48:30","guid":{"rendered":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/?p=1633"},"modified":"2026-04-03T11:12:00","modified_gmt":"2026-04-03T08:12:00","slug":"new-publication-harkos-c-et-al-2023-plos-computational-biology","status":"publish","type":"post","link":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/new-publication-harkos-c-et-al-2023-plos-computational-biology\/","title":{"rendered":"New Publication Harkos C., et al. 2023 PLOS Computational Biology"},"content":{"rendered":"<p>Intratumoral injection of immunotherapy aims to maximize its activity within the tumor. However, cytokines are cleared via tumor vessels and escape from the tumor periphery into the host-tissue, reducing efficacy and causing toxicity. Thus, understanding the determinants of the tumor and immune response to intratumoral immunotherapy should lead to better treatment outcomes. In this study, we developed a mechanistic mathematical model to determine the efficacy of intratumorally-injected conjugated-cytokines, accounting for properties of the tumor microenvironment and the conjugated-cytokines. <a href=\"https:\/\/doi.org\/10.1371\/journal.pcbi.1011740\" target=\"_blank\" rel=\"noopener\">Read more<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Intratumoral injection of immunotherapy aims to maximize its activity within the tumor. However, cytokines are cleared via tumor vessels and escape from the tumor periphery into<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":398,"featured_media":1635,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-1633","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events"],"modified_by":"kelvege","publishpress_future_action":{"enabled":false,"date":"2026-06-13 03:33:44","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts\/1633","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/users\/398"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/comments?post=1633"}],"version-history":[{"count":1,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts\/1633\/revisions"}],"predecessor-version":[{"id":1634,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts\/1633\/revisions\/1634"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/media\/1635"}],"wp:attachment":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/media?parent=1633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/categories?post=1633"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/tags?post=1633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}