{"id":1708,"date":"2024-06-28T21:10:34","date_gmt":"2024-06-28T18:10:34","guid":{"rendered":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/?p=1708"},"modified":"2026-04-03T11:11:55","modified_gmt":"2026-04-03T08:11:55","slug":"new-publication-mpekris-f-et-al-2024-cell-reports-medicine","status":"publish","type":"post","link":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/new-publication-mpekris-f-et-al-2024-cell-reports-medicine\/","title":{"rendered":"New Publication Mpekris F., et al. 2024 Cell Reports Medicine"},"content":{"rendered":"<p>Solid tumor pathology, characterized by abnormalities in the tumor microenvironment (TME), challenges therapeutic effectiveness. Mechanical factors, including increased tumor stiffness and accumulation of intratumoral forces, can determine the success of cancer treatments, defining the tumor\u2019s \u201cmechanopathology\u201d profile. These abnormalities cause extensive vascular compression, leading to hypoperfusion and hypoxia. Hypoperfusion hinders drug delivery, while hypoxia creates an unfavorable TME, promoting tumor progression through immunosuppression, heightened metastatic potential, drug resistance, and chaotic angiogenesis. <a href=\"https:\/\/doi.org\/10.1016\/j.xcrm.2024.101626\" target=\"_blank\" rel=\"noopener\">Read more<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Solid tumor pathology, characterized by abnormalities in the tumor microenvironment (TME), challenges therapeutic effectiveness. Mechanical factors, including increased tumor stiffness and accumulation of intratumoral forces, can<span class=\"excerpt-hellip\"> [\u2026]<\/span><\/p>\n","protected":false},"author":398,"featured_media":1709,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-1708","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events"],"modified_by":"kelvege","publishpress_future_action":{"enabled":false,"date":"2026-06-12 09:08:26","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts\/1708","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/users\/398"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/comments?post=1708"}],"version-history":[{"count":1,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts\/1708\/revisions"}],"predecessor-version":[{"id":1710,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts\/1708\/revisions\/1710"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/media\/1709"}],"wp:attachment":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/media?parent=1708"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/categories?post=1708"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/tags?post=1708"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}