{"id":1895,"date":"2026-06-03T13:10:30","date_gmt":"2026-06-03T10:10:30","guid":{"rendered":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/?p=1895"},"modified":"2026-06-03T13:10:30","modified_gmt":"2026-06-03T10:10:30","slug":"new-publication-kalli-m-et-al-2026-cellular-and-molecular-bioengineering","status":"publish","type":"post","link":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/new-publication-kalli-m-et-al-2026-cellular-and-molecular-bioengineering\/","title":{"rendered":"New Publication Kalli M. et al. 2026 Cellular and Molecular Bioengineering"},"content":{"rendered":"

Pancreatic ductal adenocarcinoma (PDAC) develops within a biomechanically abnormal tumor microenvironment, characterized by a dense stroma and elevated compressive forces. While extracellular matrix stiffness has been extensively studied, the impact of compressive forces on immune regulation and tumor\u2013immune interactions remains poorly understood. We integrated two complementary bioengineered compression models, a 2D transmembrane pressure device and confined 3D spheroids, with bulk transcriptomic and Liquid Chromatography\u2013Mass Spectrometry (LC-MS)\u2013based exometabolomic profiling to examine how mechanical compression shapes macrophage behaviour and tumor\u2013immune crosstalk. Controlled compressive stress (0\u20138 mmHg) was applied to macrophages, tumor cells, and tumor\u2013macrophage cocultures, followed by pathway analysis, functional assays, and multi-omic integration. Read more<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Pancreatic ductal adenocarcinoma (PDAC) develops within a biomechanically abnormal tumor microenvironment, characterized by a dense stroma and elevated compressive forces. While extracellular matrix stiffness has been [\u2026]<\/span><\/p>\n","protected":false},"author":676,"featured_media":1896,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_lmt_disableupdate":"","_lmt_disable":"","footnotes":""},"categories":[46],"tags":[],"class_list":["post-1895","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events"],"modified_by":"ahadji15","publishpress_future_action":{"enabled":false,"date":"2026-06-11 16:10:12","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"category","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts\/1895","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/users\/676"}],"replies":[{"embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/comments?post=1895"}],"version-history":[{"count":1,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts\/1895\/revisions"}],"predecessor-version":[{"id":1897,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/posts\/1895\/revisions\/1897"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/media\/1896"}],"wp:attachment":[{"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/media?parent=1895"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/categories?post=1895"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.ucy.ac.cy\/cancer-biophysics\/wp-json\/wp\/v2\/tags?post=1895"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}