The major focus of my current research is on the biomechanics and drug delivery of solid tumors. I use experimental methods in mice bearing tumors and in vitro tumor models as well as mathematical modelling to study the evolution of mechanical forces in tumors and how these forces correlate with tumors' patho-physiology and delivery of chemotherapy, nanomedicine and immunotherapy. Furthermore, I investigate strategies to optimise tumor blood vessel functionality in order to improve systemic delivery of cancer therapeutics by modifying the mechanical tumor micro-environment.
Horizon Europe, Marie Skłodowska-Curie Individual Fellowship, (MSCA-2021-PF-101065325, DL- ElastoMark), "A deep learning-derived, shear wave elastography biomarker for cancer therapy prediction". September 2022 - August 2024. €148,488.
European Research Council, Proof of Concept grant (ERC-2022-PoC1-101069207, DL-MechanoPredictor), “Deep learning derived mechanical biomarkers for cancer therapy prediction”, September 2022 - March 2024. €150,000.
National Institutes of Health (1 R01 EB032655-01A1): "A novel paradigm of sensitization of the tumor microenvironment with image-guided ultrasound cavitation and mechanotherapeutics for targeted HCC treatment", University of Cyprus budget: $121,000. PI: Professor Mike Averkiou, Department of Bioengineering, University of Washington in Seattle. September 2022-August 2026.
Horizon 2020, European High-Performance Computing Joint Undertaking (H2020-JTI-EuroHPC-2019-1, No 956201), Title: “DComEX: Data Driven Computational Mechanics at EXascale”, UCY budget: April 2021-March 2024. €250,000.
Cyprus Cancer Research Institute, “Enhancing adoptive T-cell therapy via T cell co-stimulation”, November 2021-October 2024. €200,000.
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