Κατάλογος Προσωπικού

ΤΡΙΑΝΤΑΦΥΛΛΟΣ ΣΤΥΛΙΑΝΟΠΟΥΛΟΣ

STYLIANOPOULOS TRIANTAFYLLOS
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ΑΝΑΠΛΗΡΩΤΗΣ/ΡΙΑ ΚΑΘΗΓΗΤΗΣ/ΡΙΑ
Τμήμα Μηχανικών Μηχανολογίας και Κατασκευαστικής
Green Park, 507
Λεωφ. Αγλαντζιας 91
Diploma in Chemical Engineering, 2003
National Technical University of Athens, Greece
 
PhD in Chemical Engineering, 2008
University of Minnesota, USA
 
Postdoctoral training, Department of Radiation Oncology
Massachusetts General Hospital / Harvard Medical School, USA
  
Head of Cancer Biophysics Laboratory: https://www.ucy.ac.cy/cancer-biophysics/
 
The major focus of my research is on the biomechanics, biology and drug delivery in solid tumors. I use experimental methods in mice bearing tumors and in vitro tumor models as well as mathematical modelling to study the evolution of mechanical forces in tumors and how these forces correlate with tumors' patho-physiology, biology and delivery of chemotherapy, nanomedicine and immunotherapy. Furthermore, I investigate strategies to optimise tumor blood vessel functionality in order to improve systemic delivery of cancer therapeutics by modifying the mechanical and immune tumor micro-environment.
 
For my work I have been awarded all three ERC frontier grants by the European Research Council:
an ERC Starting Grant (ReengineeringCancer, 1.44M Euros 2014-2018),
an ERC Consolidator Grant (Immuno-Predictor, 2.0M Euros 2020-2025),
an ERC Advanced Grant (MechanoResistance, 2.5M Euros, 2025-2030).
 
I have also secured more than 10.0M Euros in research funding from the EU and Cyprus. 
 
Furthermore, I am the recipient of the 2016 YC Fung Young investigator award by the Bioenginereeing Division of the American Society of Mechanical Engineers, being the first non-US resident to be awarded this prize since its establishment in 1985. (https://www.asme.org/about-asme/participate/honors-awards/achievement-awards/y-c-fung-young-investigator-award).
I am  also the recipient of the prestigious UNESCO-Equatorial Guinea Award for Research in Life Sciences (2024) https://www.unesco.org/en/articles/laureates-china-egypt-and-greece-win-unesco-equatorial-guinea-international-prize-research-life
 
I have received the Distinguished Researcher award (2021) and the Young Researcher award (2014) by the Research and Innovation Foundation of Cyprus, and the Most Cited Paper Award by the Biomedical Engineering Society of USA (BMES, 2014). My team has also received the Athanasiou Best student paper award (BMES, 2019) for the best article written by a student or a postdoc in Annals of Biomedical Engineering in 2018.
 
I have published over 150 publications in peer-reviewed journals which have received > 21,500 citations (h-index=60).
I am a member of the American Society of Mechanical Engineers (ASME), the Biomedical Engineering Society (BMES) and the European Foundation of Clinical Nanomedicine (CLINAM) and the American Association for Cancer Research (AACR).

The major focus of my current research is on the biomechanics and drug delivery of solid tumors. I use experimental methods in mice bearing tumors and in vitro tumor models as well as mathematical modelling to study the evolution of mechanical forces in tumors and how these forces correlate with tumors' patho-physiology and delivery of chemotherapy, nanomedicine and immunotherapy. Furthermore, I investigate strategies to optimise tumor blood vessel functionality in order to improve systemic delivery of cancer therapeutics by modifying the mechanical tumor micro-environment.

 FUNDING

Principal Investigator

European Research Council Consolidator Grant (ERC-CoG): Immuno-Predictor: Mechanical Biomarkers for Cancer Immunotherapy Prediction. April 2020 - March 2025 , €2,000,000
 
Horizon 2020 - Marie Skłodowska-Curie Actions Individual Fellowship Global (MSCA-IF-GF-2020-101028945 CancerCOtreat): Optimizing treatment of cancer patients infected with COVID-19 and other preconditions using mathematical modelling. May 2021 – April 2024; €256,236.

 

Horizon Europe, Marie Skłodowska-Curie Individual Fellowship, (MSCA-2021-PF-101065325, DL- ElastoMark), "A deep learning-derived, shear wave elastography biomarker for cancer therapy prediction". September 2022 - August 2024. €148,488.

European Research Council, Proof of Concept grant (ERC-2022-PoC1-101069207, DL-MechanoPredictor), “Deep learning derived mechanical biomarkers for cancer therapy prediction”, September 2022 - March 2024. €150,000.

European Research Council, Proof of Concept grant (ERC-2022-PoC2), LiveBioThx), “Live biotherapeutics to potentiate cancer immunotherapy”, March 2023 – August 2024. €150,000.
 
Partner 

National Institutes of Health (1 R01 EB032655-01A1): "A novel paradigm of sensitization of the tumor microenvironment with image-guided ultrasound cavitation and mechanotherapeutics for targeted HCC treatment", University of Cyprus budget: $121,000. PI: Professor Mike Averkiou, Department of Bioengineering, University of Washington in Seattle. September 2022-August 2026.

Horizon 2020, European High-Performance Computing Joint Undertaking (H2020-JTI-EuroHPC-2019-1, No 956201), Title: “DComEX: Data Driven Computational Mechanics at EXascale”, UCY budget: April 2021-March 2024. €250,000.

Cyprus Cancer Research Institute, “Enhancing adoptive T-cell therapy via T cell co-stimulation”, November 2021-October 2024. €200,000.

More information can be found at

https://www.ucy.ac.cy/cancer-biophysics/funding/