CONSTANTINOS PITRIS

Prof. Constantinos Pitris is currently a Professor at the KIOS Research and Innovation Center of Excellence, Department of Electrical and Computer Engineering, University of Cyprus. He is heading the “Optical Diagnostics Laboratory” which he established in 2004. Prof. Pitris has completed his studies at the University of Texas at Austin (BS Honors in Electrical Engineering, 1993, MS in Electrical Engineering, 1995), Massachusetts Institute of Technology (Ph.D. in Electrical and Medical Engineering, 2000), and Harvard Medical School (MD Magna Cum Laude in Medicine, 2002). His main research interests include the areas of optical diagnostics, biomedical imaging and spectroscopy, as well as signal/image analysis, machine learning and computational intelligence. Prof. Pitris has served as a PI or a co-PI in competitive research grants totaling over € 7 mil including a highly prestigious EU H2020 FET Open Grant, the first to be coordinated by a Cypriot institution. He is also one of the co-founders and a member of the executive committee of the KIOS Center of Excellence, which was the recipient of an EU H2020 TEMAING grant of over € 40 mil. Prof. Pitris has published 57 peer reviewed journal publications, 148 conference proceedings, 5 book chapters, and 1 book. He also holds 12 US, European and other patents, and is the cofounder of two start-up companies aiming to commercialize important research findings. The citations to his work have reached more than 15600 (with an h-index of 41) according to Google Scholar. Prof. Pitris is a grant reviewer for the European Commission, National Institutes of Health, USA, the Cyprus Ministry of Commerce, Industry and Tourism (Start-up Incubators.)
Books
- A. Boas, C. Pitris, N. Ramanujam eds. Handbook of Biomedical Optics. CRC Press, 2011. ISBN 1420090364
Selected Book Chapters
- Chen, E. Bousi, C. Pitris, and J.G. Fujimoto, “Optical Coherence Tomography: Introduction and Theory,” D. Boas, C. Pitris, N. Rammanujam, eds, CRC Press, 2011. ISBN 1420090364
- Kastanos, A. Kyriakides, K. Hadjigeorgiou, C. Pitris. “Identification and Antibiotic Sensitivity of UTI Pathogens Using Raman Spectroscopy”, in “Urinary Tract Infections”, Dr. Peter Tenke (Ed.), InTech, 2011. ISBN: 978-953-307-757-4.
- Pitris, T. Vo-Dinh, R.E. Goodson, S.E. Goodson, “Chapter 26. Medical applications of photonics” in the “Handbook of Optoelectronics: Applied Optical Electronics”, J.P. Dakin and R.G.W. Brown, eds, CRC Press, 2017. ISBN 9781138102262.
Selected Journal Articles
- J. Tearney, M. E. Brezinski, B. E. Bouma, S. A. Boppart, C. Pitris, J. F. Southern, and J. G. Fujimoto, “In vivo endoscopic optical biopsy with optical coherence tomography,” Science 276, 2037-2039, June 1997.
- G. Fujimoto, C. Pitris, S. Boppart, and M. Brezinski, “Optical coherence tomography, an emerging technology for biomedical imaging and optical biopsy,” Neoplasia 2, 9-25, January 2000.
- Bousi, I. Charalambous, C. Pitris. “Axial resolution improvement in time domain optical coherence tomography by step-frequency encoding.” Optics Express, 18:11877–11890, 2010.
- Kyriakides, E. Kastanos, K. Hadjigeorgiou, C. Pitris. “Classification of Raman spectra using the correlation kernel.” J. of Raman Spectroscopy, DOI 10.1002/jrs.2809.
- Kastanos, A. Kyriakides, K. Hadjigeorgiou, C. Pitris. "A Novel Method for Bacterial UTI Diagnosis Using Raman Spectroscopy." Int J Spectroscopy, DOI:10.1155/2012/195317, 2012.
- Bousi, I. Zouvani, and C. Pitris, "Lateral resolution improvement of oversampled OCT images using Capon estimation of weighted subvolume contribution," Biomed. Opt. Express 8(3) 1319-1331, 2017.
- Kassinopoulos, E. Bousi, I. Zouvani, C. Pitris, "The correlation of the derivative as a robust estimator of scatterer size in Optical Coherence Tomography (OCT)," Biomed. Opt. Express 8(3) 1598-1606, 2017.
- Photiou, E. Bousi, I. Zouvani, C. Pitris, "Using Speckle to Measure Tissue Dispersion in Optical Coherence Tomography," Biomed Opt. Express 8(5), 2528-2535, 2017.
- Photiou, C. Pitris, “Dual-angle optical coherence tomography for index of refraction estimation using rigid registration and cross-correlation,” Journal of biomedical optics. 24(10):106001, 2019. DOI: 10.1117/1.JBO.24.10.106001.
- Loizidou, G. Skouroumouni, C. Nikolaou, C. Pitris. “An Automated Breast Micro-Calcification Detection and Classification Technique Using Temporal Subtraction of Mammograms,” IEEE Access, 8:52785-95, 2020. DOI: 10.1109/ACCESS.2020.2980616.
- Loizidou, G. Skouroumouni, C. Pitris, C. Nikolaou. “Digital subtraction of temporally sequential mammograms for improved detection and classification of microcalcifications,” European radiology experimental 5 (1), 1-12, 2021. DOI: 10.1186/s41747-021-00238-w
- Hadjigeorgiou, E. Kastanos, C. Pitris, C. Andreou, "Surface Enhanced Raman Spectroscopy as a sensitive method for UTI diagnosis," IEEE Sensors Journal 22(11), 10063-74, 2021. DOI: 10.1109/JSEN.2021.3118107.
- Loizidou, G. Skouroumouni, C. Nikolaou, C. Pitris, “Automatic Breast Mass Segmentation and Classification Using Subtraction of Temporally Sequential Digital Mammograms,” IEEE Journal of Translational Engineering in Health and Medicine, 10, 1—11, 2022. DOI: 10.1109/JTEHM.2022.3219891
- C Photiou, M Kassinopoulos, C Pitris, “Extracting Morphological and Sub-Resolution Features from Optical Coherence Tomography Images, a Review with Applications in Cancer Diagnosis,” Photonics, 10(1), 51, 2023. DOI: 10.3390/photonics10010051
- Loizidou, R. Elia, and C. Pitris. Computer-aided breast cancer detection and classification in mammography: A comprehensive review. Computers in Biology and Medicine, p.106554, 2023.
Patents
- Richards-Kortum, C. Pitris, M. Follen-Mitchell, "Optical Probe for the Detection of Cervical Neoplasia Using Fluorescence Spectroscopy and Apparatus Incorporating Same." U. S. Patent: 5,699,795. Issued: Dec. 23, 1997.
- Richards-Kortum, A. Agrawal, C. Pitris, U. Utzinger, K. Brookner, M. Follen-Mitchell, “Acetic acid as a signal enhancing contrast agent in fluorescence spectroscopy.” U. S. Patent: 6,241,662. Issued: June 5, 2001.
- Pitris, S. A. Boppart, M. E. Brezinski, J. G. Fujimoto, "Fiber optic needle probes for optical coherence tomography imaging." U. S. Patent: 6,564,087. Issued: May 13, 2003.
- J. Tearney, B.E. Bouma, R.H. Webb, C. Pitris, M. Shishkov, “Confocal microscopy with multi-spectral encoding and system and apparatus for spectroscopically encoded confocal microscopy.” US Patent: 6,831,781. Issued: December 14, 2004.
- J. Tearney, C. Pitris, M. Shishkov, B.E. Bouma, “Microscope Objectives.” US Patent: 7,684,134. Issued: March 23, 2010.
- Odysseos, C. Pitris, A. Keramidas, “Prototype systems of theranostic biomarkers for in vivo molecular management of cancer.” US Patent: 9,890,187. Issued: February 13, 2018.
- Odysseos, C. Pitris, A. Keramidas, “Prototype systems of theranostic biomarkers for in vivo molecular management of cancer,” US Patent 10,640,524. Issued: May 5, 2020
- Richards-Kortum, C. Pitris, M. Follen Mitchell, Univ Texas, “Probe for the detection of cervical neoplasias using fluorescence spectroscopy,” Europe EP0957744. Issued: June 4, 2003.
- Follen Mitchell, C. Pitris, R. Richards-Kortum, Board Of Regents The University Of Texas System, “Probe for the detection of cervical neoplasias using fluorescence spectroscopy / Sonde destinee a la detection des neoplasies cervicales au moyen de la spectroscopie a fluorescence,” Canada CA 2215207. Issued: October 9, 2007.
- Richards-Kortum, A. Agrawal, C. Pitris, U. Utzinger, K. Brookner, M. Follen-Mitchell, “Acetic acid as a signal enhancing contrast agent in fluorescence spectroscopy.” EP1071473B1. Issued: October 10, 2010.
- Odysseos, C. Pitris, A. Keramidas, “Prototype systems of theranostic biomarkers for in vivo molecular management of cancer.” EP3108900B1. Issued: April 24, 2019.
- Odysseos, C. Pitris, A. Keramidas, “Prototype systems of theranostic biomarkers for in vivo molecular management of cancer.” US Patent 10,640,524. Issued: May 5, 2020.