Staff Catalogue


Department of Mechanical and Manufacturing Engineering
Green Park, 206
91, Aglantzias Ave.
 Dimitrios Tzeranis holds a Diploma degree (2003) in mechanical engineering from the National Technical University of Athens and the S.M. (2005) and Ph.D. (2013) degrees from Massachusetts Institute of Technology. His undergraduate studies and S.M. research focused on dynamic systems, design and robotics. His doctoral dissertation (supervised by Prof. I. Yannas and Prof. P. TC So) focused on the ability of biomaterials to induce regeneration in injured peripheral nerves. During his post-doctoral research, he was trained in biomechanics, multiplex proteomics (NTUA Systems Bioengineering lab & Protatonce Ltd, 2013-2016), stem-cell based implants and neurodegeneration (ΙΜΒΒ-FORTH, 2016-2019). He was awarded the Marie Curie Individual fellowship (2015-2017) and the ELIDEK postgraduate grant (2018-2021).

More information is available in the following links:

 Dr. Tzeranis research interests focus on developing and fabricating biomedical systems/devices that combine mechatronic systems, optical systems and biomaterials. His research builds around his world-class expertise and hands-on experience in the fabrication of Porous Collagen-based Scaffolds (PCS) and their applications.

His major research fields of interest are

  • Fabrication and characterization of PCS.
  • Cell-biomaterial interactions.
  • Biomaterial effects on stem cells, emphasizing neural stem cells.
  • Biomaterial effects on wound healing in injured organs.
  • Design, fabrication and characterization of tissue constructs based on PCS.
  • Biomaterial microfabrication
  • Biomechanics of biomaterials and tissues.
  • Optical systems, microscopy and spectroscopy, image informatics based on high content fluorescence imaging.

The major application areas of Dr. Tzeranis research are:

  • Regenerative medicine implants, emphasizing the nervous system.
  • Implantable devices for cell and drug delivery.
  • 3D tissue models for neuropharmacology studies.
Dr Tzeranis has published 19 articles in peer-reviewed journals in the fields of biomaterials, optics, medical devices and biomechanics (h-index 12).

IV Yannas, DS Tzeranis. Mammals Fail to Regenerate Organs When Wound Contraction Drives Scar Formation, npj Regenerative Medicine 6:39, 2021. doi: 10.1038/s41536-021-00149-9.

D Xydias, G Ziakas, S Psilodimitrakopoulos, A Lemonis, E Bagli, T Fotsis, A Gravanis, DS Tzeranis, E Stratakis. 3D Characterization of Collagen Remodeling in Cell-seeded Collagen Scaffolds via Polarization Second Harmonic Generation. Biomedical Optics Express 12(2): 1136-1153, 2021. doi: 10.1364/BOE.411501.

S Kechagias*, F Moschogiannaki*, E Stratakis, DS Tzeranis+, G-C Vosniakos+. Porous collagen scaffold micro-fabrication: feature-based process planning for Computer Numerically Controlled laser systems. Int. J. Adv. Manuf. Tech. 111: 749-763, 2020. doi: 10.1007/s00170-020-06131-x.

A Kourgiantaki*, DS Tzeranis*, K Karali*, C. Georgelou, E. Bampoula, S Psilodimitrakopoulos, IV Yannas, E Stratakis, K Sidiropoulou, I Charalampopoulos, A Gravanis. Neural Stem Cell Delivery via Porous Collagen Scaffolds Promotes Neuronal Differentiation and Locomotion Recovery in Spinal Cord Injury. npj Regenerative Medicine 5:12, 2020. doi: 10.1038/s41536-020-0097-0. Part of Nature’s “Leading Research in Neuroscience” highlight.

V Leva, M Chatzipetrou, D Zarifi, L Alexopoulos, DS Tzeranis, I Zergioti. Direct laser printing of liver cells on porous collagen scaffolds, Journal of Laser Micro/Nanoengineering. 13(3): 234-237, 2018. doi: 10.2961/jlmn.2018.03.0015

DS Tzeranis*, I Panagiotopoulos*, S. Gkouma, G Kanakaris, N Georgiou, N. Vaindirlis, G Vasileiou, M. Neidlin, A Ghousioudi, V Spitas, GA Macheras, LG Alexopoulos. A Device for High-Throughput Monitoring of Degradation in Soft Tissue Samples, Journal of Biomechanics 74: 180-186, 2018. doi: 10.1016/j.jbiomech.2018.04.040.

IV Yannas, DS Tzeranis, PTC So. Regeneration mechanism for skin and peripheral nerves clarified at the organ and molecular scales, Current Opinion in Biomedical Engineering 6: 1-7, 2018. doi: 10.1016/j.cobme.2017.12.002.

A Gkousioudi*, DS Tzeranis*, G Kanakaris, M Saloufas, LG Alexopoulos. A Linearized Frequency-Domain Method for Quantifying Cartilage Viscoelasticity, Annals of Biomedical Engineering 45(9):2061-2074, 2017. doi: 10.1007/s10439-017-1861-1

DS Tzeranis, EC Soller, MC Buydash, PTC So, and IV Yannas. In Situ Quantification of Surface Chemistry in Porous Collagen Biomaterials, Annals of Biomedical Engineering 44(3): 803-15, 2016. doi: 10.​1007/​s10439-015-1445-x.

JW Cha, D Tzeranis, J Subramanian, IV Yannas, E Nevidi, PTC So. Spectral-Resolved Multifocal Multiphoton Microscopy with Multianode Photomultiplier Tubes, Optics Express, 22(18): 21368 – 81, 2014. doi: 10.1364/OE.22.021368

H Choi, DS Tzeranis, JW Cha, J Moon, S DeLong, P Clémenceau, IV Yannas, and PTC So. 3D-resolved fluorescent and phosphorescence lifetime imaging using temporal focusing wide-field two-photon excitation, Optics Express 20(24): 26219 – 235, 2012. doi: 10.1364/OE.20.026219

EC Soller, DS Tzeranis, K Miu, PTC So, and IV Yannas. Common features of optimal collagen scaffolds that disrupt wound contraction and enhance regeneration both in peripheral nerves and skin, Biomaterials 33: 4783-4791, 2012. doi: 10.1016/j.biomaterials.2012.03.068

NL Sullivan*, DS Tzeranis*, Y Wang, PTC So, and DK Newman. Quantifying the Dynamics of Bacterial Secondary Metabolites by Spectral Multiphoton Microscopy, ACS Chemical Biology 6(9): 893-9, 2011. doi: 10.1021/cb200094w

IV Yannas, DS Tzeranis, BA Harley, and PTC So. Biologically active collagen-based scaffolds: advances in processing and characterization, Philosophical transactions. Series A, Mathematical, physical, and engineering sciences 368(1917): 2123-39, 2010. doi: 10.1098/rsta.2010.0015

K Myers, S Socrate, D Tzeranis, and M House. Changes in the biochemical constituents and morphologic appearance of the cervical stroma during pregnancy, European journal of obstetrics, gynecology, and reproductive biology 144 (S1): S82 -9, 2009. doi: 10.1016/j.ejogrb.2009.02.008

S McEuen, D Tzeranis, B Heymond, M Dirckx, L Lee, and A Slocum. Design of an Endoscopic Full-Thickness Lesion Removal Device, ASME Journal of Medical Devices 2(1): 015002, 2008. doi: 10.1115/1.2884269