NIKOLAS DIETIS

Dr Nikolas Dietis is an Assistant Professor of Pharmacology at the Medical School, University of Cyprus. He teaches basic pharmacology in the MD undergraduate program and pharmacogenomics in the MSc Precision Medicine program. He is the head of the Experimental Pharmacology Laboratory and the Zebrafish Laboratory at UCY. Dr Dietis is a Registered Expert by the European Commission in the field of "Pharmacology" (Reg: EX2022D543045) and "Science Communication" (Reg: D 306517), an appointed Examiner of the Cyprus State Scholarship Foundation (ID: I.K.Y.K.1.1.04.1/V), a member of the Experts Committee of the Veterinary Services of the Ministry of Agricuture of Cyprus for consultation on drug licence applications for veterinary use, an appointed Independent Evaluator at the Council of Recognition of Higher Qualifications in Cyprus (KYSATS; ID: 7.9.05.14), a certified Research Evaluator of the General Secretariat for Research and Innovation in Greece (Reg: 17609, ID: 68268), a member of the European Commission's multi-stakeholder group European AI Alliance (member ID: 53803), a member of the European Digital Education Hub on AI in Education. and a member of the Higher Education Initiative Community of the European Institute of Innovation and Technology.
Dr Dietis graduated from the University of Portsmouth (UK) with a BSc in Pharmacology, from Nottingham Trent University (UK) with a BScHons in Neuroscience & Pharmacology, from the Natural Sciences Research Centre in Nottingham Trent University (UK) with a MRes in Applied Biosciences/Neuropharmacology and from the University of Leicester (UK) with a PhD in Pharmacology. Prior to his appointment at UCY, he worked in the pharmaceutical industry sector for 5 years (Janssen-Cilag, Lavipharm) before joining the University of Tasmania (Australia) as a Lecturer in Pharmacological Sciences.
Dr Dietis has a strong interest in Medical Education and serves as a member of the Technology Enhanced Learning special-interest group at the Association for the Study of Medical Education (ASME). He received his training in the Foundations of University Learning & Teaching at the University of Tasmania (Australia) in 2013. He holds a program-based certificate in the Principles of Medical Education by the Harvard Medical School (USA), a certificate in Peer-Review of Online Courses in Higher Education by Quality Matters (USA) and a certificate in Instructional Methods in Medical Education by the University of Michigan Medical School (USA).
Dr Dietis received four teaching awards for teaching excellence and innovation in teaching practices, including the international Clinical Teacher 20th Anniversary Award by the Association for the Study of Medical Education (ASME) for the integration of AI in teaching practices.
At the University of Cyprus, Dr Dietis has served for 6 years as a member of the UCY Centre for Teaching & Learning and he is currently a member of the UCY Quality Assurance Committee. At the UCY Medical School, he is actively involved in the Accreditation process of the School's undergraduate MD and the postgraduate programs. He is also an active member of the School's Quality Assurance Committee, the Digital Examination Support Team and the Curriculum Mapping Ad Hoc Committee.
In the field of research in teaching & learning, Dr Dietis is focusing on assessment practices and technology-enhanced teaching practices in Medical Education. He has development an assessment-based learning matrix at UCY as a tool for supporting self-paced & self-directed learning for Medical students. He has also developed the UCY Medical School's Teaching-Research Nexus as a course development tool. In addition, his team has recently developed the ‘Drug Index Visual Map’, which is the first open, digital, visual mapping tool for drug classification and was presented at the World Congress of Basic & Clinical Pharmacology in 2023.
Dr Dietis has been trained in Prompt Engineering with ChatGPT by Vandrebilt University (USA) and is interested in the Integration of AI in Teaching & Learning. He is currently serving as a member of the UCY Vice Rector's Ad-Hoc Committee in Artificial Intelligence and has been involved in UCY's activites on AI. Dr Dietis is particularly interested in the use of generative-AI tools, like ChatGPT in teaching and learning. He has led a global survey on the use of generative-AI in teaching & learning in Medicine, supported by ASME and the participation of WFME.
RESEARCH (BRIEF SUMMARY)
Dr Dietis has been actively engaged in basic & translational research in molecular pharmacology for more than a decade. He has secured funding from national & international competitive grants and has published his research in high-quality international scientific journals. He has presented his work at various national and international conferences and has been an invited speaker at scientific meetings & symposia. Since 2012, he has supervised 18 postgraduate & doctorate students who have been awarded with 6 research excellence awards.
In 2020, Dr Dietis & his collaborators received the Best Paper Award from the Institute of Electrical and Electronics Engineers (IEEE) at the GLOBECOM2020 International Conference for their work on “Growing Bio-Nanomachine Networks: Application to Malignant Tumor Evolution and Progression”. In 2026 he is launching the zBRAIN study: the first ever co-clinical trial in Cyprus that integrates newly diagnosed patients (glioblastoma) with patient-derived animal models (zebrafish) for predicting therapeutic outcomes.
For more details, check the Research Interests tab above.
SOCIAL OUTREACH
Dr Dietis is a passionate science communicator for drug science, with a vigorous public outreach profile through a number of newspaper articles, TV and radio interviews, social media and open-to-public talks & presentations, that aim to educate & engage the general public with evidence-based drug science against misinformation. His social outreach is published openly at his YouTube channel. Dr Dietis is particularly publicly-active on Twitter, where he often publishes educational threads on the appropriate use of drugs and vaccines. He is the producer of the DrugTalk podcast, published on Spotify, Apple Music, Amazon and YouTube. Dr Dietis is also the creator of the Substack newsletter that publishes content around teaching & learning, called Forward Teaching.
For Dr Dietis' Social Media & BioLinks Click Here.
Dr. Dietis' research interests centre on zebrafish human-cancer xenografts as a rapid translational in vivo platform for drug discovery and repurposing across multiple cancer types, including brain, prostate, breast and hepatic cancers. He is particularly interested in the role of synergistic multi-target pharmacology on cancer cell communication and migration, with a focus on glioblastoma.
In 2016, Dr Dietis established the Experimental Pharmacology Laboratory at the Medical School University of Cyprus; the first drug-screening research unit in Cyprus, focusing on translational drug discovery and repurposing, toxicology and behavioural pharmacology assays. The aim of the lab is to play an important role in translational pharmacology in Cyprus, in alignment with the Smart Specialization Strategy of the Republic of Cyprus (Health Section, Priority C: "Development of Safe & Effective Drugs"). The lab uses modern equipment against various screening methods to evaluate pharmacological efficacy and assess toxicological parameters of novel or approved drugs against disease models.
In 2018, Dr Dietis founded the first Zebrafish Laboratory in Cyprus, that focuses on toxicological and pharmacological assays in vivo for drug profiling & phenotyping against human disease models.
Dr. Dietis’ current research focuses on zebrafish patient-derived xenografts (“Zebrafish Avatars”) as a translational platform for personalized oncology. He recently secured national funding to launch the first co-clinical study in Cyprus (the zBRAIN study), employing Zebrafish Avatars derived from newly diagnosed glioblastoma patients in order to validate their predictive power for therapeutic outcomes and accelerate personalized treatment selection in neuro-oncology.
Dr. Dietis holds a FELASA-recognized Certificate of Competence on Zebrafish & Medaka for Research Purposes (ATF; German Academy for Veterinary Medicine) and serves on the Experts Committee of the Veterinary Services of the Ministry of Agriculture of Cyprus, providing consultation on new veterinary drug licence applications.
Dr. Dietis is a member of the Hellenic Society for Basic and Clinical Pharmacology (HSBCP), the British Pharmacological Society (BPS), the European Zebrafish Society (EZS) and the international Zebrafish Disease Model Society (ZDMS). Since 2026 he is serving as an appointed member of the Cancer Committee of the International Union of Basic & Clinical Pharmacology (IUPHAR) and an Ambassador of the European Association of Cancer Research (EACR).
For more details about Dr Dietis' lab and current research projects and news, visit dietislab.org.
Recent (last 5-year) Publications
- Yin X, Germanos O, Dietis N. Reduction in locomotor activity and freezing time: A dual measure for more accurate fear response in rats. Behav Processes. 2025 Mar;226:105176.
- Klavaris A, Koufaris C, Noberini R, Kouma M, Demetriadou C, Ghiringhelli A, Dietis N, Bonaldi T, Kirmizis A. H2A.X N-terminal acetylation is a newly identified NAA40-mediated modification that is responsive to UV irradiation. Epigenetics Chromatin. 2025 Jul 16;18(1):46. doi: 10.1186/s13072-025-00608-3.
- Dietis N, Allegaert K, Smits E and Ceci A. Editorial: Supporting pediatric drug development: from basic research to clinical studies and technological advancements. Front. Pediatr. 2024; 12:1477420.
- Savva K, Zachariou M, Bourdakou MM, Dietis N, Spyrou GM. DReAmocracy: A Method to Capitalise on Prior Drug Discovery Efforts to Highlight Candidate Drugs for Repurposing. International Journal of Molecular Sciences. 2024; 25(10):5319.
- Gregoriou Y, Gregoriou G, Manoli A, Papageorgis P, McLarney B, Vangeli D, McColman S, Yilmaz V, Hsu H, Skubal M, Ogirala A, Athanasiou E, Cramb D, Dietis N, Strati K, Itskos G, Constantinou A, Andreou C. Photophysical and biological assessment of coumarin-6 loaded polymeric nanoparticles as a cancer imaging agent. Sens. Diagn., 2023,2, 1277-1285.
- Savva K, Zachariou M, Kynigopoulos D, Fella E, Vitali M-I, Kosofidou X, Spyrou M, Sargiannidou I, Panayiotou E, Dietis N.,Spyrou G. Preliminary In Vitro and In Vivo Insights of In Silico Candidate Repurposed Drugs for Alzheimer’s Disease. Life, 2023, 13, 1095.
- Minadakis G, Tomazou M, Dietis N, Spyrou GM. Vir2Drug: a drug repurposing framework based on protein similarities between pathogens. Brief Bioinform. 2023 Jan 19;24(1):bbac536.
- Savva K, Zachariou M, Bourdakou MM, Dietis N, Spyrou GM. Network-based stage-specific drug repurposing for Alzheimer's disease. Comput Struct Biotechnol J. 2022 Mar 16;20:1427-1438.
- Paul, A.K.; Woolley, K.L.; Rahmatullah, M.; Wilairatana, P.; Smith, J.A.; Gueven, N.; Dietis, N. Differential Effects of a Novel Opioid Ligand UTA1003 on Antinociceptive Tolerance and Motor Behaviour. Pharmaceuticals 2022, 15, 789.
- Hamidieh AE, Dietis N, Samoylenko A, Meiser I, Nicolaou N, Abdelrady E, Zhyvolozhnyi A, Vainio S, Odysseos O. Optically Active Bionanomachine Interfaces Build Therapeutic Nanonetworks for Glioblastoma Multiforme. 2022 IEEE 16th International Symposium on Medical Information and Communication Technology (ISMICT).
- Tomazou M, Bourdakou M, Minadakis G, Zachariou M, Oulas, Karatzas E, Loizidou E, Kakouri A, Christodoulou C, Savva K, Zanti M, Onisiforou A, Afxenti S, Richter J, Christodoulou C, Kyprianou T, Kolios G, Dietis N, Spyrou G. Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19. Briefings in Bioinformatics, Volume 22, Issue 6, November 2021, bbab114.
- Gregoriou Y, Gregoriou G, Yilmaz V, Kapnisis K, Prokopi M, Anayiotos A, Strati K, Dietis N, Constantinou AI, Andreou C. Resveratrol loaded polymeric micelles for theranostic targeting of breast cancer cells. Nanotheranostics, 2021, 5(1):113-124.
- Paul, A.K., Gueven, N, Dietis, N. Profiling the Effects of Repetitive Morphine Administration on Motor Behavior in Rats. Molecules 2021, 26, 4355.
- Paul, A.K. Smith, C.M. Rahmatullah, M. Nissapatorn, V. Wilairatana, P. Spetea, M. Gueven, N. Dietis, N. Opioid Analgesia and Opioid-Induced Adverse Effects: A Review. Pharmaceuticals 2021, 14, 1091.
- Middleton N, Tsioutis C, Kolokotroni O, Heraclides A, Theodosis-Nobelos P, Mamais I, Pantelidou M, Tsaltas D, Christaki E, Nikolopoulos G, Dietis N. Gaps in Knowledge About SARS-CoV-2 & COVID-19 Among University Students Are Associated With Negative Attitudes Toward People With COVID-19: A Cross-Sectional Study in Cyprus. Front Public Health. 2021 Nov 19;9:758030.