Staff Catalogue

Savvas Georgiades

GEORGIADES SAVVAS
+357-22892779
...
ASSISTANT PROFESSOR
Department of Chemistry
FST 02 - Faculty of Pure and Applied Sciences, B146
University Campus
  • Assistant Professor, University of Cyprus (July 2018-).
  • Lecturer, University of Cyprus (Aug. 2011-Jun. 2018).
  • Lecturer in Pharmacy and Chemistry, Kingston University, Kingston Upon Thames, UK (Aug. 2010-Jul. 2011).
  • Postdoctoral Research Associate in Chemical Biology, Imperial College, London, UK (Nov. 2007-Jul. 2010), with Prof. Ramon Vilar.
  • Postdoctoral Research Associate in Synthetic Organic Chemistry, The Scripps Research Institute, La Jolla, CA, USA (Sep. 2006-Oct. 2007), with Prof. Phil Baran.
  • PhD in Organic Chemistry/Chemical Biology, Harvard University, Cambridge, MΑ, USA (Jan. 2003-Jun. 2006), with Prof. Jon Clardy.
  • Full-time PhD Student in Organic Chemistry, Cornell University, Ithaca, NΥ, USA (Sep. 2001-Dec. 2002, Ph.D. completed at Harvard University), with Prof. Jon Clardy.
  • BSc in Chemistry, University of Cyprus, Nicosia, Cyprus (Sep. 1997-Jul. 2001). Diploma thesis with Prof. Costas Patrickios. Awarded 2nd Prize of the President of the Republic of Cyprus (2001), 1st Prize of the School of Pure and Applied Sciences (2001) (GPA 9.2/10).
Dr Savvas N. Georgiades is Assistant Professor in the Department of Chemistry, University of Cyprus and the Head of the Synthetic Organic Chemistry and Chemical Biology Laboratory (est. 2012). He has obtained his BSc in Chemistry from University of Cyprus (2001) and his PhD in Organic Chemistry and Chemical Biology from Harvard University (2006). After postdoctoral appointments at the Scripps Research Institute - La Jolla, California (Organic Synthesis, 2006-2007) and Imperial College London (Chemical Biology, 2007-2010), he worked for one year as independent Lecturer in Pharmacy and Chemistry at Kingston University (UK), before joining University of Cyprus in 2011. He was promoted to Assistant Professor in 2018. His research expertise spans the areas of Organic Synthesis, Bioorganic and Medicinal Chemistry. His current research interests include: (a) Development of innovative synthetic technologies for C-H bond activation and C-C or C-X (X=heteroatom) bond formation, especially metal-mediated/catalyzed, and applications (SNG has been the Cyprus Representative on the Management Committee of COST Action CA15106, CHAOS: C-H Activation in Organic Synthesis); (b) Development of new DNA G-quadruplex ligands as a basis for new anti-cancer treatments and bio-imaging chemical agents (SNG has been a Member of COST Action CM1106: Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells); (c) Synthesis of biomaterials from nucleobase self-assembly for energy applications. (d) Synthesis and biological evaluation of small-molecule modulators for cellular signaling pathways. Dr Georgiades currently supervises 4 doctoral students (PhD) and 3 undergraduate (diploma thesis) students. In the past he has supervised 1 doctoral student (PhD), 4 postgraduate, Master-level students (MSc) and 12 diploma thesis students (BSc), all of whom have successfully completed their studies. He teaches various courses in Organic Chemistry, Medicinal Chemistry and Bioorganic Chemistry on both the undergraduate and postgraduate level. He has co-authored about 30 scientific publications (including 3 book chapters) and has presented his work in more than 30 scientific conferences. He has organized 2 international conferences in Cyprus (COST CA15106 Meeting-2019, EuCheMS ODYIW-2014), and has recently participated in the Scientific Committee of the 13th Chemistry Cyprus-Greece Conference 2019. He has been the Cyprus national representative for 5 consecutive years in the prestigious EuCheMS Organic Division Young Investigators Workshop (2012-2016) and an Erasmus+ Staff Mobility for Teaching Scholar at Queen Mary University of London (School of Engineering and Materials Science) in 2017. Dr Georgiades also serves on the Editorial Boards of Referees of several international chemistry journals and serves as reviewer for more than 30 scientific journals. He has also served as scientific reviewer for proposals submitted in the course of european funding schemes (2021: SONATA, National Science Center, Poland; 2022: YERUN Research Mobility Awards; 2023,2024: APVV Slovakia Research and Development Agency). He has been a member of the team responsible for the recent translation in Greek of the book "Organic Chemistry" (6th edition) by Loudon and Parise, published by Broken Hill Publishers in 2019. He is a Member of the Pancyprian Union of Chemists (ΠΕΕΧ), a member of the American Chemical Society (ACS), a Member of the International Chemical Biology Society (ICBS) and a Fellow of the Higher Education Academy, UK.
  • Metal-catalyzed C-H bond activation for generation of bioactive compounds and molecular libraries: Ru-photoredox-mediated, Pd-catalyzed (sp2) C-H arylation of phenyl-pyridines/phenyl-pyrimidines; Pd-catalyzed (sp2) C-H fluorination of phenyl-pyrimidines; Pd/Cu-cocatalyzed (sp2) C-H activation of oxazoles and C-C cross-coupling to bromopyridines; (sp2) C-H platination of phenyl-pyridines; (sp3) C-H hydroxylation and C-H amidation on terpenoid substrates.                                                                                         
  • Design and synthesis of novel families of ligands/binders/stabilizers and optical probes/bioimaging agents against guanine-quadruplex (G-quadruplex) DNAs and RNAs of anticancer interest (telomeric, oncogene promoters, 5’-UTRs of RNAs, ribosomal DNA, etc): Organoplatinum(II) agents bearing aminoacid-reminiscent peripheral groups; all-organic oligomers with aryl-aryl connectivity, generated via 1,3-dipolar cycloaddition reactions (pyridyl-oxazoles, pyridyl-isooxazoles, pyridyl-triazoles).                                              
  • Multi-step syntheses of bioactive terpenoid and terpenoid-carbazole alkaloid hybrid natural products, starting from “chiral pool” precursors.                                                                                                                                                                                                     
  • Self-assembly of nucleobases and organic dyes to afford G-tetrad-based biomaterials for energy applications.

1. “Oligomeric Pyridyl-Triazoles: Structural Determinants of their Interaction with Topologically Diverse G-Quadruplexes of Anticancer Interest” (working title) Savva, L.; Georgiades, S. N.* (corresponding author), in preparation.

2. "Towards Clinical Development of Scandium Radioisotope Complexes for Use in Nuclear Medicine: Encouraging Prospects with the Chelator 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and its Derivatives" (working title) Ioannidis, I.; Lefkaritis, G.; Georgiades, S. N.; Pashalidis, I.; Kontoghiorges, G. J., 2024, submitted.

3. “LED-induced Ru-photoredox Pd-catalyzed C-H Arylation of (6-Phenylpyridin-2-yl)pyrimidines and Heteroaryl Counterparts” Antoniou, I.; Ioannou, N.; Panagiotou, N.; Georgiades, S. N.* (corresponding author), RSC Adv. 2024, 14, 12179-12191.

4. “The Synthesis and Applications of Bioactive Phenoxazinones” Georgiades, S. N.* (corresponding author), Adv. Heterocyclic Chem. 2024, 143, 27-93. (book chapter, invited)

5. “Catalysis of a Diels-Alder Reaction between Azachalcones and Cyclopentadiene by a Recyclable Copper(II)-PEIP Metal-Organic Framework” Hadjikyprianou, E.; Petrides, S.; Kourtellaris, A.; Tasiopoulos, A.; Georgiades, S. N.* (corresponding author)Materials 2023, 16, 5298, doi: 10.3390/ma16155298.

6. "Stereocontrolled Barbier Reactions for Generation of Homoallylic Alcohols: New Applications in the Synthesis of Natural Products" Petrides, S.; Georgiades, S. N.* (corresponding author) Trends Org. Chem. 202223, 1-32.

7. "Gaining Insights on the Interactions of a Class of Decorated (2-([2,2’-Bipyridin]-6-yl)phenyl)platinum Compounds with c-Myc Oncogene Promoter G-Quadruplex and Other DNA Structures" Savva, L.; Fossépré, M.; Keramidas, O.; Themistokleous, A.; Rizeq, N.; Panagiotou, N.; Leclercq, M.; Nicolaidou, E.; Surin, M.; Hayes, S. C.; Georgiades, S. N.* (corresponding author) Chem. Eur. J. 202228, e202201497, doi: 10.1002/chem.202201497.

8. "N-Directed Pd-Catalyzed Photoredox-Mediated C–H Arylation for Accessing Phenyl-Extended Analogues of Biginelli/Suzuki-Derived Ethyl 4-Methyl-2,6-Diphenyl-pyrimidine-5-Carboxylates" Georgiades, S. N.* (corresponding author); Nicolaou, P. G.; Panagiotou, N. Catalysts 202111, 1071, doi: 10.3390/catal11091071.

9. "G-Quadruplexes: Emerging Anticancer Roles" Georgiades, S. N.* (corresponding author) E Scholarly Community Encyclopedia 2021, https://encyclopedia.pub/8534.

10. "Recent Developments in Small-Molecule Ligands of Medicinal Relevance for Harnessing the Anticancer Potential of G-Quadruplexes" Savva, L.; Georgiades, S. N.* (corresponding author) Molecules 2021, 26, 841, doi:10.3390/molecules26040841.

11. "A Novel Conjugate of Bis[((4-bromophenyl)amino)quinazoline], a EGFR-TK Ligand, with a Fluorescent Ru(II)-Bipyridine Complex Exhibits Specific Subcellular Localization in Mitochondria" Ilmi, R.; Tseriotou, E.; Stylianou, P.; Christou, Y. A.; Ttofi, I.; Dietis, N.; Pitris, C.; Odysseos, A. D.; Georgiades, S. N.* (corresponding author) Mol. Pharmaceutics 201916, 4260-4273.

12. "Recent Advances in Carbazole Syntheses" Georgiades, S. N.* (corresponding author); Nicolaou P. G. Adv. Heterocyclic Chem. 2019, 129, 1-88. (book chapter, invited)

13. "Investigation of 'Head-to-Tail'-Connected Oligoaryl N,O-Ligands as Recognition Motifs for Cancer-Relevant G-Quadruplexes" Rizeq, N.; Georgiades, S. N.* (corresponding author) Molecules 201722, 2160, doi: 10.3390/molecules22122160.

14. “Linear and Branched Pyridyl-Oxazole Oligomers: Synthesis and Circular Dichroism Detectable Effect on c-Myc G-Quadruplex Helicity” Rizeq, N.; Georgiades, S. N.* (corresponding author) Eur. J. Org. Chem. 2016, 122-131.

15. “Synthesis of a ‘Propeller-Like’ Oligoheteroaryl with Alternating Pyridine and Oxazole Motifs” Georgiades, S. N.* (corresponding author); Rizeq, N. Synlett 2015, 26, 489-493.

16. "In situ polymerised polyamide 6/sepiolite nanocomposites: Effect of different interfaces" Bilotti, E.; Duquesne, E.; Deng, H.; Zhang, R.; Quero, F.; Georgiades, S. N.; Fischer, H. R.; Dubois, P.; Peijs, T. Eur. Polymer J. 2014, 56, 131-139.
 

17. “Antibiotics: Modes of Action and Considerations” (in Greek) Georgiades, S. N.* (corresponding author), Journal of the Pancyprian Society of Chemists (ΠΕΕΧ), issue 13 (Mar. 2014), pp. 15-22. (monograph, invited)

18. “Pleckstrin Homology Domain-Mimicking Small Molecule Binds Phosphatidyl Inositol (4,5)-Biphosphate with High Affinity and Specificity” Mak, L. H.; Georgiades, S. N.; Rosivatz, E.; Mirabelli, M.; Vilar, R.; Woscholski, R. ACS Chem. Biol. 2011, 6, 1382-1390.
 
19. “Inhibition of Mitogen-Activated Protein Kinase (MAPK) and Cyclin-Dependent Kinase 2 (Cdk2) by Platinum(II) Phenanthroline Complexes” Child, E. S.; Georgiades, S. N.; Rose, K. N.; Stafford, V. S.; Patel, C. B. K.; Steinke, J. H. G.; Mann, D. J.; Vilar, R. J. Chem. Biol. 2011, 4, 159-165.
 
20. “Identification of a Potent Activator of Akt Phosphorylation from a Novel Series of Phenolic, Picolinic, Pyridino and Hydroxamic Zinc(II) Complexes” Georgiades, S. N.; Mak, L. H.; Angurell, I.; Rosivatz, E.; Mohd Mustapa, M. F.; Polychroni, C.; Woscholski, R.; Vilar, R. J. Biol. Inorg. Chem. 2011, 16, 195-208.
 
21. “Interactions of Metal Complexes with G-Quadruplex DNA” Georgiades, S. N.; Abd-Karim, N. H.; Suntharalingam, K.; Vilar, R. Angew. Chem., Int. Ed. 2010, 49, 4020-4034; “Wechselwirkung von Metallcomplexen mit G-Quadruplex-DNA” Georgiades, S. N.; Abd-Karim, N. H.; Suntharalingam, K.; Vilar, R. Angew. Chem. 2010, 122, 4114-4128. (highly-cited paper)
 
22. “Interactions of Metal Complexes with Nucleic Acids” Georgiades, S. N.; Vilar, R. Ann. Rep. Prog. Chem. A: Inorg. Chem. 2010106, 481-503. (book chapter, invited)
 
23. “FOXO3a is Broadly Neuroprotective In Vitro and In Vivo Against Insults Implicated in Motor Neuron Diseases” Mojsilovic-Petrovic, J.; Nedelsky, N.; Boccitto, M.; Mano, I.; Georgiades, S. N.; Zhou, W.; Liu, Y.; Neve, R. L.; Taylor, J. P.; Driscoll, M.; Clardy, J.; Merry, D.; Kalb, R. G. J. Neurosci. 2009, 29, 8236-8247.
 
24. “Synthetic Libraries of Tyrosine-Derived Bacterial Metabolites” Georgiades, S. N.; Clardy, J. Bioorg. Med. Chem. Lett. 2008, 18, 3117-3121.
 
25. “Preparation of a Psammaplysene-Based Library” Georgiades, S. N.; Clardy, J. Org. Lett. 2006, 8, 4251-4254.
 
26. “Total Synthesis of Psammaplysenes A and B, Naturally Occurring Inhibitors of FOXO1a Nuclear Export” Georgiades, S. N.; Clardy, J. Org. Lett. 2005, 7, 4091-4094.
 
27. “Synthesis and Characterization of Double-Hydrophilic Model Networks Based on Cross-Linked Star Polymers of Poly(Ethylene Glycol) Methacrylate and Methacrylic Acid” Georgiades, S. N.; Vamvakaki, M.; Patrickios, C. S. Macromolecules 2002, 35, 4903-4911.