Staff Catalogue
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PANTELIS GEORGIADES

GEORGIADES PANTELIS
22892888
...
ASSOCIATE PROFESSOR
Department of Biological Sciences
FST 02 - Faculty of Pure and Applied Sciences, B161
University Campus

Dr Pantelis Georgiades is an Associate Professor and head of the 'Developmental Biology and Stem Cell Lab' which carries out biomedical research in the Department of Biological Sciences at the University of Cyprus. His broad research interest is the understanding of how the fertilized egg transforms itself into the human body. His laboratory explores this using mouse embryos and embryo-derived stem cells as exparimental models.

Dr Georgiades trained in the United Kingdom and Canada. He first attended the University of London [BSc Hons in ‘Molecular Biology’ from 'Queen Mary’ and PhD in ‘Developmental Biology’ from 'UCL’, while receiving scholarships from the ‘Wellcome Trust', 'A.G. Leventis Foundation' and the ‘Gatsby Charitable Foundation']. He then joined the University of Cambridge where he undertook postdoctoral training in developmental biology at the Department of Anatomy with Prof. A.C. Ferguson-Smith and Prof. G.J. Burton, while being a recipient of a 'Wellcome Trust' fellowship. His further training was in stem cell and developmental biology and took place in Canada, as a post-doctoral research fellow at the 'Samuel Lunenfeld Research Institute' of 'Mount Sinai Hospital' with Prof. J. Rossant. 

Dr Georgiades and his research team have received research grant awards from national and international funding agencies including 'Research and Innovation Foundation' (RIF, Cyrpus), the 'University of Cyprus' (Cyprus), the A.G. Leventis Foundation (Cyprus), the 'Wellcome Trust' (UK), the Gatsby Foundation (UK) and the 'Samuel Lunenfeld Research Institute' (Canada).

Dr Georgiades is: (a) an editorial board member of various international scientific journals such as 'Scientific Reports', (b) a member of the "British Society for Developmental Biology" and (c) an evaluator of research grant applications from international funding agencies such as the "Medical Research Council" (MRC) of the United Kingdom.

Dr Georgiades and his research team have published in several peer-reviewed scientific journals including “Proceedings of the National Academy of Sciences of the United States of America (PNAS)”, “Development”, “Placenta” και “Nature Communications”.

The broad research goal of our Lab is to understand how the structurally simple fertilized egg transforms itself into the increadibly complex human body. Our research centers on understanding this fascinating phenomenon which is central to regenerative medicine, using mouse embryos and placentas as in vivo models and embryo-derived stem cells as in vitro models. We investigate this at the molecular, cellular and tissue levels.
 
Our current research focuses on four themes:
1.  Embryonic development: the development of the epiblast (earliest progenitor of the adult body) and the brain in vivo, and of epiblast stem cells in vitro.
2. Extraembryonic development: the development of early trophoblast (progenitor of the placenta) in vivo and of trophoblast stem cells in vitro.
3. Extraembryonic influences (from early trophoblast and placenta) on embryo development, growth and viability.
4. Development of the placenta and tissues of the uterus during pregnancy in vivo.
 
Our functional research tools include: (a) the use of gene knockout and transgenic mice and stem cells, (b) the use of signaling molecules and small molecule inhibitors of signalling pathways in cultured embryos, embryo fragments and stem cells, (c) gene knockdowns in stem cells, (d) microsurgery of cultured embryos, and (e) derivation of novel embryo-derived stem cells and their culture under various conditions so as to mimic aspects of embryonic and extraembryonic development.  
 
Experimental assesment of the consequences of our functional assays include the identification of cell types, cell states and their relative spatial arragments based on gene expression (e.g., using RNA in situ hybridization, RT-PCR and RNA sequencing), protein localization (e.g., IF - immunoflurescene) and histology (e.g., of paraffin or frozen sections). In addition, we image these using conventional microscopy (e.g., fluorescent or phase contrast imaging), confocal miscroscopy and time-lapse miscroscopy.
 
Our discoveries have been published in international scientific journals such as “Proceedings of the National Academy of Sciences of the United States of America (PNAS)”, “Development”, "Biochemical and Biophysical Research Communications", “Placenta” and“Nature Communications”.
 

For more information please visit the "Georgiades lab" website: https://pantelisgeorgiades.wixsite.com/thegeorgiadeslab 

 

* corresponding author

  • Hadjikypri, X., Theofanous, C., Christodoulidi, A. and Georgiades, P*., (2024). New findings on the orientation of the mouse anterior-posterior (AP) axis before and during the initiation of gastrulation using a more refined embryo staging. Biochemistry and Biophysics Reports, 40, p.101817.
 
  • Elia, A. and Georgiades, P*., (2021). Investigation of the pregnancy-induced muscle bundle dispersal of the inner myometrium of adult mouse uterus and its relationship to the metrial gland/MLAp. Biochemical and Biophysical Research Communications, 584, pp.66-72.
  • Nikolaou, S., Hadjikypri, X., Ioannou, G., Elia, A. and Georgiades P* (2018). Functionaland phenotypic distinction of the firsttwotrophoblast subdivisions and identification of the border between them during early postimplantation: A prerequisite for understanding early patterning during placentogenesis. Biochemical and Biophysical Research Communications,496.1 (2018): 64-69
  • Birol, O., Ohyama, T., Edlund, R. K., Drakou, K., Georgiades, P.,& Groves, A. K. (2016). The mouse Foxi3 transcription factor is necessary for the development of posterior placodes. Developmental biology, 409, 139-151.
  • Drakou, K., & Georgiades, P* (2015). A serum-free and defined medium for the culture of mammalian postimplantation embryos. Biochemical and biophysical research communications,468(4), 813-819.
  •  Polydorou C, Georgiades P* (2013). Ets2-dependent trophoblast signallingis required for gastrulation progression after primitive streak initiation. Nature communications, 4, 1658.
  •  Charalambous C, Drakou K, Nicolaou, S, Georgiades P*(2013). Novel spatiotemporal glycome changes in the murine placenta during placentation based on BS‐I lectin binding patterns. Anatοmical Record296, 921-932.
  •  Charalambous F, Elia A, Georgiades P*(2012) Decidual spiral artery remodeling during earlypost-implantation period in mice: Investigation of associations with decidual uNKcells and invasive trophoblast. Biochem. Biophys. Res. Commun.417, 847-852.
  •  Elia A, Charalambous F, Georgiades P*(2011) New phenotypic aspects of the decidual spiral artery wall during early post-implantation mouse pregnancy. Biochem. Biophys. Res. Commun.416, 211-216.
  •  OdiatisC, Georgiades P*(2010) New insights for Ets2 function in trophoblast using lentivirus-mediated gene knockdown in trophoblast stem cells.Placenta31, 630-640. 
  • Georgiades P*, Cox B, Gertsenstein M, Chawengsaksophak K, Rossant J (2007) Trophoblast-specific gene manipulation using lentivirus-based vectors. BioTechniques42, 317-325. 
  •  Georgiades P and Rossant J (2006) Ets2 is necessary introphoblast for normal embryonic anteroposterior axis development. Development 133, 1059-1068. 
  •  Georgiades P* (2004) The possible clinical relevance of mouse placental research. SICC(Invited expert section), 17-12-2004.
  •  Georgiades P*, Ferguson-Smith AC, Burton GJ (2002) Comparative developmental anatomy of murine and human definitive placentae. Placenta23, 3-19. 
  •  Georgiades P, Ogilvy S, Duval H, Licence DR, Charnock-Jones DS, Smith SK, Print CG (2002) VavCre transgenic mice: a tool for mutagenesis in hematopoietic and endothelial lineages. Genesis34, 251-6. 
  •  Georgiades P, Watkins M, Burton GJ, Ferguson-Smith AC (2001) Roles for genomic imprinting and the zygotic genome in placental development. Proceedings of the National Academy of Sciences USA 98, 4522-4527. 
  •  Ferguson-Smith AC, Tevendale M, Georgiades P, Grandjean (2001) Balanced translocations for the analysis of imprinted regions of the mouse genome. Methods in Molecular Biology181, 41-54. 
  •  Georgiades P, Watkins M, Surani MA, Ferguson-Smith AC (2000) Parental origin-specific developmental defects in mice with uniparental disomy for chromosome 12. Development127, 4719-28. 
  •  Takada S, Tevendale M, Baker J, Georgiades P, Campbell E, Freeman T, Johnson MH, Paulsen M, Ferguson-Smith AC (2000) Delta-like and gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12. Current Biology 10, 1135-8. 
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