New Publication Hadjigeorgiou, A. G. et al. 2026 Frontiers in Immunology

Local radiotherapy rarely triggers regression of distant, non-irradiated tumors (the “abscopal” effect), but this outcome is unpredictable because it depends on interacting processes, such as antigen release, antigen presentation, T-cell priming and trafficking, and lymphoid health. To study these interactions quantitatively and identify dominant mechanisms that control off-target tumor responses, we built an integrated physiologically based pharmacokinetic – quantitative systems pharmacology (PBPK-QSP) model. The PBPK-QSP model identifies specific, actionable mechanisms controlling abscopal responses and suggests three complementary strategies to increase the chance of abscopal responses. Read more