New Publication Kalli M. et al. 2026 Cellular and Molecular Bioengineering
June 3, 2026
The efficacy of conventional chemotherapy in solid tumors remains limited due to tumor microenvironment barriers that impede efficient drug transport and compromise therapeutic outcomes. Thermosensitive liposomes (TSLs) combined with focused ultrasound-induced hyperthermia offer a promising strategy for localized, temperature-triggered drug release. Despite experimental progress, a quantitative understanding of the coupled physical and biological mechanisms underlying this therapy is yet to be fully elucidated. Here, a three-dimensional multiphysics computational model was developed to investigate the interplay between focused ultrasound-induced hyperthermia and temperature-sensitive liposome-mediated drug delivery in solid tumors, integrating acoustic propagation, tissue heating and temperature-dependent drug release. Model predictions were validated against published experimental data, demonstrating good agreement with tumor growth and intratumoral drug concentration data. Sensitivity analysis showed that focused ultrasound parameters and liposome properties strongly influence treatment efficacy. Read more
