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The efficacy of conventional chemotherapy in solid tumors remains limited due to tumor microenvironment barriers that impede efficient drug transport and compromise therapeutic outcomes. Thermosensitive liposomes […]

Pancreatic ductal adenocarcinoma (PDAC) develops within a biomechanically abnormal tumor microenvironment, characterized by a dense stroma and elevated compressive forces. While extracellular matrix stiffness has been […]

Immunotherapy has transformed cancer treatment but remains ineffective in many solid tumors, largely due to the immunosuppressive tumor microenvironment (TME). A dense/stiff extracellular matrix (ECM) can […]

Transgelin is an actin-binding protein that promotes cancer progression via activation of cancer-associated fibroblasts and has been identified as a prognostic marker. However, its distribution and […]

The advancements in computational biology in tandem with the explosion of machine learning (ML) have the potential to revolutionize quantitative and personalized medicine. In this framework, […]

Local radiotherapy rarely triggers regression of distant, non-irradiated tumors (the “abscopal” effect), but this outcome is unpredictable because it depends on interacting processes, such as antigen […]

Breast palpation is a widely accepted preliminary exam for early tumor detection. However, it carries substantial risk of incorrect assessment due to its operatordependent nature. Tactile […]

Predicting neoadjuvant chemotherapy response in breast cancer remains critical for optimizing treatment strategies, yet robust predictive biomarkers are lacking. This study implemented an ensemble machine learning […]

Blood–tumor barriers pose a major obstacle in treating solid tumors by hindering the efficient delivery of therapeutic agents. Unlike the organized vasculature of normal tissues, tumor […]

Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense stroma and dysfunctional vasculature, limiting drug delivery and immune infiltration, while melanoma, though less fibrotic, remains highly […]

The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) poses major barriers to the efficacy of anticancer therapies, particularly through features such as desmoplasia, elevated stiffness, […]

Glucocorticoid steroids are widely prescribed in oncology for managing treatment-related side effects, though their use is discouraged in patients undergoing immune checkpoint blockade (ICB). Given the […]

Abnormal blood vessels limit the delivery and function of endogenous T cells as well as adoptively transferred Chimeric Antigen Receptor (CAR)-T cells in tumor microenvironment (TME). […]

The success of mRNA vaccines against infectious diseases such as COVID-19 has opened new avenues for their application in oncology. In cancer immunotherapy, mRNA vaccines—typically encapsulated […]

The gut microbiome has emerged as a key regulator of response to cancer immunotherapy. However, a better understanding of the underlying mechanisms by which the microbiome […]

Inefficient drug delivery in tumors, especially in desmoplastic cancers, arises from blood vessel collapse due to tumor stiffening and mechanical compression. Vessel collapse also leads to […]

Data-driven decision-making in radiation oncology (RO) relies on integrating real-world data effectively. Synthetic data (SD), generated through machine learning, offers a solution by mimicking real-world data […]

Nano-immunotherapy shows great promise in improving patient outcomes, as seen in advanced triple-negative breast cancer, but it does not cure the disease, with median survival under […]

Bone marrow (BM) has roles in health and disease, so systemically administered nanocarriers (NCs) targeting or avoiding BM are desirable. While the hydrodynamic diameter of NCs […]

The mechanical properties of the tumor microenvironment (TME) undergo significant changes during tumor growth, primarily driven by alterations in extracellular (ECM) stiffness and tumor viscoelasticity. These […]

Mathematical modelling has proven to be a valuable tool in predicting the delivery and efficacy of molecular, antibody-based, nano and cellular therapy in solid tumours. Mathematical […]

Solid tumors harbor a complex and dynamic microenvironment that hinders the delivery and efficacy of therapeutic interventions. In this study, we developed and utilized a hybrid, […]

Pancreatic cancer remains one of the most lethal malignancies, with limited treatment options and poor prognosis. A common characteristic among pancreatic cancer patients is the biomechanically […]

To have the desired therapeutic effect, nanomedicines and macromolecular medications must move from the site of injection to the site of action, without having adverse effects. […]

In the era of personalized cancer treatment, understanding the intrinsic heterogeneity of tumors is crucial. Despite some patients responding favorably to a particular treatment, others may […]

Solid tumor pathology, characterized by abnormalities in the tumor microenvironment (TME), challenges therapeutic effectiveness. Mechanical factors, including increased tumor stiffness and accumulation of intratumoral forces, can […]

Critical illness, such as severe COVID-19, is heterogenous in presentation and treatment response. However, it remains possible that clinical course may be influenced by dynamic and/or […]

We are hiring! The Cancer Biophysics Laboratory is looking for a postdoctoral fellow with an expertise in microbiology, molecular cloning techniques and experience with genetically engineering […]